Piperidine-4-carboxamide as a new scaffold for designing secretory glutaminyl cyclase inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2020.12.118
Abstract: Alzheimer's disease (AD), a common chronic neurodegenerative disease, has become a major public health concern. Despite years of research, therapeutics for AD are limited. Overexpression of secretory glutaminyl cyclase (sQC) in AD brain leads to… read more here.
Keywords: glutaminyl cyclase; carboxamide new; new scaffold; piperidine carboxamide ... See more keywords
3(2H)-pyridazinone derivatives: a new scaffold for novel plant activators
Sign Up to like & getrecommendations! Published in 2019 at "RSC Advances"
DOI: 10.1039/c9ra06892a
Abstract: Due to the emergence of drug resistance, pesticide residue and environmental contamination, it is important to develop novel eco-friendly strategies to protect plants. read more here.
Keywords: pyridazinone derivatives; novel plant; plant activators; new scaffold ... See more keywords
Madecassic Acid—A New Scaffold for Highly Cytotoxic Agents
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23084362
Abstract: Due to their manifold biological activities, natural products such as triterpenoids have advanced to represent excellent leading structures for the development of new drugs. For this reason, we focused on the syntheses and cytotoxic evaluation… read more here.
Keywords: scaffold highly; cytotoxicity; madecassic acid; highly cytotoxic ... See more keywords
Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer’s Disease Therapy
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25143190
Abstract: Alzheimer’s disease (AD) is multifactorial disease characterized by the accumulation of abnormal extracellular deposits of amyloid-beta (Aβ) peptide, and intracellular neurofibrillary tangles (NFTs), along with dramatic neuronal death and decreased levels of choline acetyltransferase. Given… read more here.
Keywords: alzheimer disease; disease; new scaffold; triazolopyridopyrimidine new ... See more keywords
Bis(2,6-pyrazolyl)pyridines as a New Scaffold for Coordination Polymers
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DOI: 10.3390/molecules28114275
Abstract: Two coordination polymers, Fe(LOBF3)(CH3COO)(CH3CN)2]n•nCH3CN and [Fe(LO−)2AgNO3BF4•CH3OH]n•1.75nCH3OH•nH2O (LO− = 3,3′-(4-(4-cyanophenyl)pyridine-2,6-diyl)bis(1-(2,6-dichlorophenyl)-1H-pyrazol-5-olate)), were obtained via a PCET-assisted process that uses the hydroxy-pyrazolyl moiety of the ligand and the iron(II) ion as sources of proton and electron, respectively. Our… read more here.
Keywords: coordination; pyrazolyl pyridines; new scaffold; bis pyrazolyl ... See more keywords