A new series of thiosemicarbazone‐based anti‐inflammatory agents exerting their action through cyclooxygenase inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200136
Abstract: In an endeavor to identify potent anti‐inflammatory agents, new thiosemicarbazones (TSCs) incorporated into a diaryl ether framework (2a–2l) were prepared and screened for their in vitro inhibitory effects on cyclooxygenases (COXs). 4‐[4‐(Piperidin‐1‐ylsulfonyl)phenyl]‐1‐[4‐(4‐cyanophenoxy)benzylidene]thiosemicarbazide (2c) was the… read more here.
Keywords: series thiosemicarbazone; cox; inflammatory agents; anti inflammatory ... See more keywords
Toward a treatment of diabesity: In vitro and in vivo evaluation of uncharged bromophenol derivatives as a new series of PTP1B inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.01.057
Abstract: Protein tyrosine phosphatase 1B (PTP1B) has been considered as a validated biological target for type 2 diabetes treatment, but past endeavors to develop inhibitors of PTP1B into drugs have been unsuccessful. Two challenging aspects are… read more here.
Keywords: compound could; ptp1b; compound; new series ... See more keywords
Identification of a new series of flavopiridol-like structures as kinase inhibitors with high cytotoxic potency.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112355
Abstract: In this work, unique flavopiridol analogs bearing thiosugars, amino acids and heterocyclic moieties tethered to the flavopiridol via thioether and amine bonds mainly on its C ring have been prepared. The analogs bearing thioether-benzimidazoles as… read more here.
Keywords: identification new; cytotoxic; flavopiridol like; series flavopiridol ... See more keywords
Continued fractions and q-series generating functions for the generalized sum-of-divisors functions
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Number Theory"
DOI: 10.1016/j.jnt.2017.05.023
Abstract: Abstract We construct new continued fraction expansions of Jacobi-type J-fractions in z whose power series expansions generate the ratio of the q-Pochhammer symbols, ( a ; q ) n / ( b ; q )… read more here.
Keywords: series generating; generating functions; series; divisors functions ... See more keywords
N-(thiazol-2-yl)benzamide derivatives as a new series of supramolecular gelators: Role of methyl functionality and S⋯O interaction
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Solid State Chemistry"
DOI: 10.1016/j.jssc.2019.121027
Abstract: Abstract A new series of N-(thiazol-2-yl) benzamide derivatives were synthesized, characterized and investigated for their gelation behavior with the aim to elucidate the role of methyl functionality and multiple non-covalent interactions on gelation/non-gelation behavior using… read more here.
Keywords: thiazol benzamide; role methyl; interaction; new series ... See more keywords
Design, Synthesis, and Evaluation of a New Series of Hydrazones as Small-Molecule Akt Inhibitors for NSCLC Therapy
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c02331
Abstract: In an endeavor to identify small molecules for the management of non-small-cell lung carcinoma, 10 new hydrazone derivatives (3a–j) were synthesized. MTT test was conducted to examine their cytotoxic activities against human lung adenocarcinoma (A549)… read more here.
Keywords: design synthesis; evaluation new; series; new series ... See more keywords
Synthesis of new series of quinoline derivatives with insecticidal effects on larval vectors of malaria and dengue diseases
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-08397-5
Abstract: Mosquito borne diseases are on the rise because of their fast spread worldwide and the lack of effective treatments. Here we are focusing on the development of a novel anti-malarial and virucidal agent with biocidal… read more here.
Keywords: dengue; quinoline; new series; series quinoline ... See more keywords
Superhalogens as building blocks of a new series of superacids
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DOI: 10.1039/c7nj00129k
Abstract: Strong superacids, such as HSbF6, typically consist of Bronsted/Lewis acid components (e.g., HF/SbF5). Using MP2/6-311++G(d,p) calculations, we propose a new series of superacids by the protonation of BnH3n+1− superhalogen anions. The resulting BnH3n+2 species behave… read more here.
Keywords: building blocks; series superacids; bnh3n; superhalogens building ... See more keywords
Synthesis and Characterization of a New Series of Binuclear Pd(II) Biscatecholato Complexes: Non-Innocent Ligand-Based Approach to a Wide Range of Variation in Near-Infrared Absorptions of Mixed-Valence Complexes
Sign Up to like & getrecommendations! Published in 2018 at "Bulletin of the Chemical Society of Japan"
DOI: 10.1246/bcsj.20180187
Abstract: In this study, we report synthesis of a new series of mixed-valence (MV) complexes having intervalence charge transfer (IVCT) energies variable from the first to the third telecommunication window.... read more here.
Keywords: valence complexes; new series; mixed valence; synthesis characterization ... See more keywords
New Series of VEGFR-2 Inhibitors and Apoptosis Enhancers: Design, Synthesis and Biological Evaluation
Sign Up to like & getrecommendations! Published in 2022 at "Drug Design, Development and Therapy"
DOI: 10.2147/dddt.s344750
Abstract: Background Cancer is still a major world health threat, causing a high rate of mortality. VEGFR-2 inhibitor anticancer agents are of great significance. However, they showed some serious side effects. Purpose To discover new effective… read more here.
Keywords: compound; vegfr; vegfr inhibitor; new series ... See more keywords
A New Series of Asynchronous Frequency-Controlled Motors for Mining Excavators
Sign Up to like & getrecommendations! Published in 2019 at "Russian Electrical Engineering"
DOI: 10.3103/s1068371219040060
Abstract: This article provides the results of designing and developing the production of a new series of asynchronous low-voltage (LV) motors with a squirrel-cage rotor for mining excavators. The operating conditions of electric motors used in… read more here.
Keywords: frequency controlled; mining excavators; series asynchronous; new series ... See more keywords