Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models
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DOI: 10.1021/acscentsci.7b00465
Abstract: Protein stabilization is fundamental to enzyme function and evolution, yet understanding the determinants of a protein’s stability remains a challenge. This is largely due to a shortage of atomically detailed models for the ensemble of… read more here.
Keywords: prediction new; new stabilizing; stabilizing mutations; markov state ... See more keywords