Recent advances and new strategies on leishmaniasis treatment.
Sign Up to like & getrecommendations! Published in 2020 at "Applied microbiology and biotechnology"
DOI: 10.1007/s00253-020-10856-w
Abstract: Leishmaniasis is one of the most important tropical neglected diseases according to the World Health Organization. Even after more than a century, we still have few drugs for the disease therapy and their great toxicity… read more here.
Keywords: advances new; new strategies; treatment; leishmaniasis treatment ... See more keywords
New strategies for managing adult gliomas
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurology"
DOI: 10.1007/s00415-020-09884-3
Abstract: Gliomas are hard to treat. Their prognosis has improved little over the past few decades. Fundamental therapeutic challenges such as treatment resistance, malignant progression, and tumour recurrence persist. New strategies are needed to advance the… read more here.
Keywords: adult gliomas; new strategies; treatment; strategies managing ... See more keywords
New strategies to identify protease substrates.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2020.09.009
Abstract: Proteome dynamics is governed by transcription, translation, and post-translational modifications. Limited proteolysis is an irreversible post-translational modification that generates multiple but unique proteoforms from almost every native protein. Elucidating these proteoforms and understanding their dynamics… read more here.
Keywords: medicine; protease substrates; strategies identify; protease ... See more keywords
Towards new strategies to manage livestock reproduction using kisspeptin analogs.
Sign Up to like & getrecommendations! Published in 2018 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2017.08.026
Abstract: The discovery of the hypothalamic neuropeptide kisspeptin and its receptor (KISS1R) have dramatically improved our knowledge about the central mechanisms controlling reproduction. Kisspeptin neurons could be considered the hub where internal and external information controlling… read more here.
Keywords: reproduction; controlling reproduction; new strategies; towards new ... See more keywords
New strategies to treat AML: novel insights into AML survival pathways and combination therapies
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-01069-1
Abstract: The effective treatment of acute myeloid leukemia (AML) is very challenging. Due to the immense heterogeneity of this disease, treating it using a “one size fits all” approach is ineffective and only benefits a subset… read more here.
Keywords: combination; new strategies; novel insights; aml survival ... See more keywords
PI3K inhibitors: review and new strategies
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Science"
DOI: 10.1039/d0sc01676d
Abstract: The search is on for effective specific inhibitors for PI3Kα mutants. read more here.
Keywords: new strategies; review new; pi3k inhibitors; inhibitors review ... See more keywords
New strategies for economically feasible CO2 electroreduction using a porous membrane in zero-gap configuration
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Materials Chemistry A"
DOI: 10.1039/d1ta03182a
Abstract: Technoeconomic analysis (TEA) sensitivity results for a CO2RR system with porous membrane (PM). read more here.
Keywords: porous membrane; new strategies; economically feasible; feasible co2 ... See more keywords
New strategies for patenting biological medicines used in rheumatoid arthritis treatment
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2018.1502748
Abstract: ABSTRACT Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by an inflammatory process, with a global prevalence ranging from 0.3% to 1%. The overall cost of RA drugs is estimated in $20 billion… read more here.
Keywords: new strategies; treatment; rheumatoid arthritis; patenting biological ... See more keywords
Targeting autophagy in disease: established and new strategies.
Sign Up to like & getrecommendations! Published in 2021 at "Autophagy"
DOI: 10.1080/15548627.2021.1936359
Abstract: Macroautophagy/autophagy is an evolutionarily conserved pathway responsible for clearing cytosolic aggregated proteins, damaged organelles or invading microorganisms. Dysfunctional autophagy leads to pathological accumulation of the cargo, which has been linked to a range of human… read more here.
Keywords: targeting chimera; new strategies; kinase; disease ... See more keywords
New strategies to combat workplace incivility and promote joy
Sign Up to like & getrecommendations! Published in 2023 at "Nursing"
DOI: 10.1097/01.nurse.0000891960.69075.73
Abstract: Abstract: Eighty-five percent of nurses report incivility in healthcare. Promoting a culture of civility—from nursing school to the workplace—is vital to ensuring healthy learning and work environments and ultimately safe patient care. This article presents… read more here.
Keywords: new strategies; combat workplace; workplace incivility; incivility ... See more keywords
High-efficiency prime editing enables new strategies for broad-spectrum resistance to bacterial blight of rice.
Sign Up to like & getrecommendations! Published in 2023 at "Plant biotechnology journal"
DOI: 10.1111/pbi.14049
Abstract: Using genetic resistance against bacterial blight (BB) caused by Xanthomonas oryzae pathovar oryzae (Xoo) is a major objective in rice breeding programmes. Prime editing (PE) has the potential to create novel germplasm against Xoo. Here,… read more here.
Keywords: new strategies; resistance bacterial; prime editing; rice ... See more keywords