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   Articles with "new structural" as a keyword



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New structural insights into the oligosaccharide phosphate fraction of Pichia (Hansenula) holstii NRRL Y2448 phosphomannan.

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recommendations! Published in 2017 at "Carbohydrate research"

DOI: 10.1016/j.carres.2017.05.008

Abstract: The oligosaccharide phosphate fraction (OPF) obtained from mild acid hydrolysis of P. holstii NRRL Y-2448 phosphomannan is the starting material for the preparation of the Phase III anticancer drug candidate PI-88. The OPF was for the… read more here.

Keywords: holstii nrrl; phosphate fraction; oligosaccharide phosphate; new structural ... See more keywords

Hexaniobate Cluster Anion Monolayers on Gold Nanoparticles: A New Structural Role for Alkali Metal Countercations.

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recommendations! Published in 2019 at "Inorganic chemistry"

DOI: 10.1021/acs.inorgchem.8b03139

Abstract: Monolayer shells of polyoxotungstate cluster anions on gold nanoparticles in water were electrostatically stabilized by structurally integrated countercations, with formation constants, K, increasing in the order: Li+ < Na+ < K+ < TMA+ < Cs+… read more here.

Keywords: gold nanoparticles; alkali metal; hexaniobate cluster; new structural ... See more keywords

A New Structural Model of Enzymatic Lignin with Multiring Aromatic Clusters

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recommendations! Published in 2022 at "ACS Omega"

DOI: 10.1021/acsomega.2c01812

Abstract: Lignin is a natural aromatic compound in plants. Several lignin structural models have been proposed in the past years, but all the models cannot be converted to benzene carboxylic acids (BCAs) for all aromatic rings… read more here.

Keywords: lignin; aromatic clusters; structural model; new structural ... See more keywords

Biosynthesis and trafficking of heme o and heme a: new structural insights and their implications for reaction mechanisms and prenylated heme transfer

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recommendations! Published in 2021 at "Critical Reviews in Biochemistry and Molecular Biology"

DOI: 10.1080/10409238.2021.1957668

Abstract: Abstract Aerobic respiration is a key energy-producing pathway in many prokaryotes and virtually all eukaryotes. The final step of aerobic respiration is most commonly catalyzed by heme-copper oxidases embedded in the cytoplasmic or mitochondrial membrane.… read more here.

Keywords: biosynthesis; trafficking heme; heme; new structural ... See more keywords

Identification of a new structural family of SGK1 inhibitors as potential neuroprotective agents

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recommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"

DOI: 10.1080/14756366.2022.2153841

Abstract: Abstract SGK1 is a serine/threonine kinase involved in several neurodegenerative-related pathways such as apoptosis, neuroinflammation, ionic channel regulation, and autophagy, among others. Despite its potential role as a pharmacological target against this kind of diseases,… read more here.

Keywords: identification new; new structural; sgk1 inhibitors; structural family ... See more keywords

New structural insights into the control of the retinoic acid receptors RAR/RXR by DNA, ligands, and transcriptional coregulators

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recommendations! Published in 2025 at "Nucleic Acids Research"

DOI: 10.1101/2025.03.18.643890

Abstract: Retinoic acid receptors (RARs) are ligand-dependent transcription factors essential for various biological processes, including embryogenesis, differentiation, and apoptosis. RARs function as heterodimers with retinoid X receptors (RXRs) and regulate gene expression via retinoic acid response… read more here.

Keywords: retinoic acid; rar rxr; new structural; structural insights ... See more keywords

New structural insights into Fe2P2O7 – unravelling an unresolved dispute and three reversible phase transitions

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recommendations! Published in 2025 at "IUCrJ"

DOI: 10.1107/s2052252525007547

Abstract: Thortveitite-related Fe2P2O7 shows three reversible phase transitions and has an incommensurately modulated crystal structure at room temperature. read more here.

Keywords: three reversible; phase transitions; reversible phase; structural insights ... See more keywords

New Structural Modifications of Cotarnine Alkaloid Derivatives: Cotarnone and Dihydrocotarnine

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recommendations! Published in 2020 at "Russian Journal of General Chemistry"

DOI: 10.1134/s1070363220020127

Abstract: Abstract Simplest derivatives of the cotarnine alkaloid, like cotarnone and 1,2-dihydrocotarnine, undergo electrophilic Einhorn acylamidomethylation (with 60–95% yield) and sulfochlorination with chlorosulfonic acid at position 5. At the same time cotarnone and its derivatives undergo… read more here.

Keywords: cotarnone dihydrocotarnine; modifications cotarnine; structural modifications; alkaloid derivatives ... See more keywords

Abstract IA05: Uncovering new structural insights into RAS interactions with effectors and regulators

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recommendations! Published in 2023 at "Molecular Cancer Research"

DOI: 10.1158/1557-3125.ras23-ia05

Abstract: RAS proteins, which act as binary molecular switches, are implicated in approximately 20% of all cancer cases and are known to play a critical role in the initiation and progression of some of the deadliest… read more here.

Keywords: structural insights; effectors regulators; ras interactions; new structural ... See more keywords

In silico studies provide new structural insights into trans-dimerization of β1 and β2 subunits of the Na+, K+-ATPase

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recommendations! Published in 2025 at "PLOS One"

DOI: 10.1371/journal.pone.0321064

Abstract: The Na+, K+-ATPase is an electrogenic transmembrane pump located in the plasma membrane of all animal cells. It is a dimeric protein composed of α and β subunits and has a third regulatory subunit (γ)… read more here.

Keywords: studies provide; trans dimerization; insights trans; silico studies ... See more keywords

Galectin-10: a new structural type of prototype galectin dimer and effects on saccharide ligand binding.

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recommendations! Published in 2018 at "Glycobiology"

DOI: 10.2210/pdb5xrl/pdb

Abstract: Galectin-10 (Gal-10) which forms Charcot-Leyden crystals in vivo, is crucial to regulating lymph cell function. Here, we solved the crystal structures of Gal-10 and eight variants at resolutions of 1.55-2.00 A. Structural analysis and size… read more here.

Keywords: galectin; new structural; dimer; ligand binding ... See more keywords