New 3‐Substituted‐2‐(4‐hydroxyanilino)pyridine Derivatives: Synthesis, Antitumor Activity, and Tubulin Polymerization Inhibition
Sign Up to like & getrecommendations! Published in 2017 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201600256
Abstract: A series of new pyridine derivatives 4a–c, 5a–d, 6a–d, 7a–f, and 8a–f structurally related to ABT‐751 were synthesized and characterized by spectroscopic means and elemental analysis. All the synthesized compounds were tested for their cytotoxic… read more here.
Keywords: new substituted; inhibition; substituted hydroxyanilino; tubulin ... See more keywords
New substituted pyrazolones and dipyrazolotriazines as promising tyrosyl-tRNA synthetase and peroxiredoxin-5 inhibitors: Design, synthesis, molecular docking and structure-activity relationship (SAR) analysis.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104704
Abstract: New substituted pyrazolone and dipyrazolotriazine derivatives have been synthesized, designed and well characterized as promising dual antimicrobial/antioxidant agents to overcome multidrug resistant bacteria (MDR), oxidative stress and their related diseases. Among all strains, S. aureus… read more here.
Keywords: new substituted; activity relationship; structure activity; activity ... See more keywords
Synthesis of new 2-substituted pyrazolo[5,1-b][1,3]oxazoles via Sonogashira coupling reactions in water
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.04.062
Abstract: Abstract New 2-substituted pyrazolo[5,1- b ][1,3]oxazoles are synthesized through the Sonogashira coupling reaction of 2-iodomethyl-6-methylpyrazolo[5,1- b ][1,3]oxazole with terminal alkynes in the presence of a palladium catalyst. This process is carried out in the absence… read more here.
Keywords: synthesis new; water; sonogashira coupling; new substituted ... See more keywords
Synthesis of Some New Substituted Thieno[2,3-d]pyrimidine Derivatives as Antimicrobial Agents
Sign Up to like & getrecommendations! Published in 2019 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363219070247
Abstract: A series of thieno-pyrimidine derivatives are synthesized from 5′-amino-2,3′-bithiophene-4′-carboxylate via the corresponding intermediate N-benzoylated carboxamide derivatives. The target compounds are tested for antibacterial and antifungal activity. Some of the synthesized compounds demonstrate potent antibacterial activity… read more here.
Keywords: thieno pyrimidine; derivatives antimicrobial; substituted thieno; synthesis new ... See more keywords
Synthesis of New Substituted 3-(Thien-2-yl)imino-3H-furan-2-ones
Sign Up to like & getrecommendations! Published in 2020 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363220060031
Abstract: The intramolecular cyclization of substituted 4-oxo-4-(het)aryl-2-(thiophen-2-ylamino)but-2-enoic acids in the presence of acetic or propionic anhydride afforded a series novel substituted 3-(thien-2-yl)iminofuran-2(3H)-ones. read more here.
Keywords: imino furan; synthesis new; thien imino; substituted thien ... See more keywords
New Substituted Benzoylthiourea Derivatives: From Design to Antimicrobial Applications
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25071478
Abstract: The increasing threat of antimicrobial resistance to all currently available therapeutic agents has urged the development of novel antimicrobials. In this context, a series of new benzoylthiourea derivatives substituted with one or more fluorine atoms… read more here.
Keywords: antimicrobial applications; benzoylthiourea derivatives; new substituted; substituted benzoylthiourea ... See more keywords