Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout.
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DOI: 10.1021/acs.jmedchem.2c00149
Abstract: NLRP3 is involved in the pathophysiology of several inflammatory diseases. Therefore, there is high current interest in the clinical development of new NLRP3 inflammasome small inhibitors to treat these diseases. Novel N-sulfonylureas were obtained by… read more here.
Keywords: synthesis pharmacological; new sulfonylureas; pharmacological evaluation; nlrp3 inflammasome ... See more keywords