Inflammation and insulin resistance: New targets encourage new thinking
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201700036
Abstract: Galectin‐3 and LTB4 are pro‐inflammatory molecules recently shown to directly cause insulin resistance in mouse and human cells. They are highly expressed in the obese state, and can be targeted both genetically and pharmacologically to… read more here.
Keywords: insulin; insulin resistance; inflammation insulin; new targets ... See more keywords
Evaluation of advanced, pathophysiologic new targets for imaging of CNS
Sign Up to like & getrecommendations! Published in 2023 at "Drug Development Research"
DOI: 10.1002/ddr.22040
Abstract: The inadequate information about the in vivo pathological, physiological, and neurological impairments, as well as the absence of in vivo tools for assessing brain penetrance and the efficiency of newly designed drugs, has hampered the… read more here.
Keywords: evaluation; new targets; pathophysiologic new; advanced pathophysiologic ... See more keywords
New Targets and Emergent Therapies for Osteoporosis.
Sign Up to like & getrecommendations! Published in 2019 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2019_329
Abstract: The 11 existing FDA-approved osteoporosis drug treatments include hormone replacement therapy, 2 SERMs (raloxifene and bazedoxifene), 5 inhibitors of bone-resorbing osteoclasts (4 bisphosphonates and anti-RANKL denosumab), 2 parathyroid hormone analogues (teriparatide and abaloparatide), and 1… read more here.
Keywords: therapies osteoporosis; targets emergent; drug; pharmacology ... See more keywords
New targets for HIV drug discovery.
Sign Up to like & getrecommendations! Published in 2019 at "Drug discovery today"
DOI: 10.1016/j.drudis.2019.03.013
Abstract: Recent estimates suggest close to one million people per year die globally owing to HIV-related illnesses. Therefore, there is still a need to identify new targets to develop future treatments. Many of the more recently… read more here.
Keywords: targets hiv; drug; new targets; hiv drug ... See more keywords
Androgens and endometrium: New insights and new targets
Sign Up to like & getrecommendations! Published in 2018 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2017.09.022
Abstract: Androgens are synthesised in both the ovary and adrenals in women and play an important role in the regulation of female fertility, as well as in the aetiology of disorders such as polycystic ovarian syndrome,… read more here.
Keywords: tissue; insights new; androgens endometrium; new insights ... See more keywords
Are there new targets for juvenile idiopathic arthritis?
Sign Up to like & getrecommendations! Published in 2019 at "Seminars in arthritis and rheumatism"
DOI: 10.1016/j.semarthrit.2019.09.017
Abstract: Juvenile idiopathic arthritis (JIA) is not a disease but an umbrella term that gather all forms of chronic arthritis of unknown origin and with onset in childhood. Some of these disorders appear to be the… read more here.
Keywords: juvenile idiopathic; idiopathic arthritis; targets juvenile; new targets ... See more keywords
Cancer Physical Hallmarks as New Targets for Improved Immunotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2021.03.011
Abstract: A low response rate is the major challenge for existing cancer immunotherapies. Physical cues in the tumor microenvironment (TME) have been recognized as new hallmarks of cancer, which may synergistically contribute to low immunotherapy response.… read more here.
Keywords: targets improved; cancer physical; improved immunotherapy; physical hallmarks ... See more keywords
Diffuse large B-cell lymphoma: new targets and novel therapies
Sign Up to like & getrecommendations! Published in 2021 at "Blood Cancer Journal"
DOI: 10.1038/s41408-021-00456-w
Abstract: Newer, more effective and non-cytotoxic therapies are an unmet need for patients with diffuse large B-cell lymphoma (DLBCL) and other B-cell malignancies. Recently approved agents include polatuzumab with bendamustine and rituximab, selinexor, and tafasitamab plus… read more here.
Keywords: cell; lymphoma new; large cell; new targets ... See more keywords
Tetracyclines, a promise for neuropsychiatric disorders: from adjunctive therapy to the discovery of new targets for rational drug design in psychiatry
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000585
Abstract: Major mental disorders, such as schizophrenia, bipolar disorder, and major depressive disorder, represent the leading cause of disability worldwide. Nevertheless, the current pharmacotherapy has several limitations, and a large portion of patients do not respond… read more here.
Keywords: adjunctive therapy; targets rational; neuropsychiatric disorders; new targets ... See more keywords
Motor synergy generalization framework for new targets in multi-planar and multi-directional reaching task
Sign Up to like & getrecommendations! Published in 2022 at "Royal Society Open Science"
DOI: 10.1098/rsos.211721
Abstract: Humans can rapidly adapt to new situations, even though they have redundant degrees of freedom (d.f.). Previous studies in neuroscience revealed that human movements could be accounted for by low-dimensional control signals, known as motor… read more here.
Keywords: multi directional; new targets; motor synergy; motor ... See more keywords
Retinal and choroidal angiogenesis: a review of new targets
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Retina and Vitreous"
DOI: 10.1186/s40942-017-0084-9
Abstract: Retinal and choroidal neovascularization are a major cause of significant visual impairment, worldwide. Understanding the various factors involved in the accompanying physiopathology is vital for development of novel treatments, and most important, for preserving patient… read more here.
Keywords: family; growth factor; retinal choroidal; new targets ... See more keywords