New therapeutic concepts in bile acid transport and signaling for management of cholestasis
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28991
Abstract: The identification of the key regulators of bile acid (BA) synthesis and transport within the enterohepatic circulation has revealed potential targets for pharmacological therapies of cholestatic liver diseases. Novel drug targets include the bile BA… read more here.
Keywords: transport signaling; transport; new therapeutic; therapeutic concepts ... See more keywords
Targeting Aged Astrocytes May Be a New Therapeutic Strategy in Parkinson's Disease
Sign Up to like & getrecommendations! Published in 2018 at "Movement Disorders"
DOI: 10.1002/mds.27387
Abstract: CHWG holds a MRC Clinician Scientist fellowship, and receives grants from the Rosetrees Trust, the Evelyn Trust and Addenbrooke’s Charitable Trust. She is also supported by the NIHR Cambridge Biomedical Research Centre. KMS holds a… read more here.
Keywords: astrocytes may; therapeutic strategy; targeting aged; may new ... See more keywords
Erythropoiesis and chronic kidney disease–related anemia: From physiology to new therapeutic advancements
Sign Up to like & getrecommendations! Published in 2019 at "Medicinal Research Reviews"
DOI: 10.1002/med.21527
Abstract: Erythropoiesis is triggered by hypoxia and is strictly regulated by hormones, growth factors, cytokines, and vitamins to ensure an adequate oxygen delivery to all body cells. Abnormalities in one or more of these factors may… read more here.
Keywords: chronic kidney; physiology; new therapeutic; erythropoiesis ... See more keywords
The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites.
Sign Up to like & getrecommendations! Published in 2021 at "Medicinal research reviews"
DOI: 10.1002/med.21804
Abstract: Calcium channels (CCs), a group of ubiquitously expressed membrane proteins, are involved in many pathophysiological processes of protozoan parasites. Our understanding of CCs in cell signaling, organelle function, cellular homeostasis, and cell cycle control has… read more here.
Keywords: calcium; calcium homeostasis; protozoan parasites; new therapeutic ... See more keywords
New Therapeutic Uses for Existing Drugs.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-67144-4_14
Abstract: Eighty percent of drugs that enter human clinical testing are never approved for use. This means that for every five drugs that make it into the clinic, there are four that failed to show effectiveness… read more here.
Keywords: uses existing; pharmacology; biology; new therapeutic ... See more keywords
New therapeutic approaches for brainstem tumors: a comparison of delivery routes using nanoliposomal irinotecan in an animal model
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-017-2681-8
Abstract: Despite the advances in imaging, surgery and radiotherapy, the majority of patients with brainstem gliomas die within 2 years after initial diagnosis. Factors that contribute to the dismal prognosis of these patients include the infiltrative nature… read more here.
Keywords: approaches brainstem; delivery; therapeutic approaches; new therapeutic ... See more keywords
A New Therapeutic Approach to Obesity: Stroke?
Sign Up to like & getrecommendations! Published in 2017 at "Obesity Surgery"
DOI: 10.1007/s11695-017-2604-y
Abstract: Obesity was declared a global health epidemic in 2003 by the World Health Organization. Control of eating in the human brain is provided by several neural systems. Decision-making and cognitive control (prefrontal cortex, cingulate), food… read more here.
Keywords: approach obesity; control; obesity stroke; new therapeutic ... See more keywords
New Therapeutic Strategies for Lewy Body Dementias
Sign Up to like & getrecommendations! Published in 2017 at "Current Neurology and Neuroscience Reports"
DOI: 10.1007/s11910-017-0778-2
Abstract: This article reviews current treatment strategies and recent advances for the Lewy body dementias (LBDs). Current available symptom treatment strategies are based on monoaminergic, cholinergic and glutaminergic neurotransmitter systems. Relatively robust evidence exists for cholinesterase… read more here.
Keywords: disease; therapeutic strategies; new therapeutic; lewy body ... See more keywords
New Therapeutic Options for Fragile X Syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Current Treatment Options in Neurology"
DOI: 10.1007/s11940-019-0551-8
Abstract: Purpose of reviewThe purpose of this review is to provide an overview of current research and clinical practice guidelines in fragile X syndrome (FXS) with regard to therapeutic approaches in the management of this condition.… read more here.
Keywords: therapeutic options; fragile syndrome; options fragile; new therapeutic ... See more keywords
Treatments for COVID-19: Lessons from 2020 and new therapeutic options
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Pharmacology"
DOI: 10.1016/j.coph.2021.11.002
Abstract: To face the COVID-19 pandemic, prophylactic vaccines have been developed in record time, but vaccine coverage is still limited, accessibility is not equitable worldwide, and the vaccines are not fully effective against emerging variants. Therefore,… read more here.
Keywords: therapeutic options; covid lessons; lessons 2020; new therapeutic ... See more keywords
New Therapeutic Targets in Alzheimer's Disease
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Gerontology"
DOI: 10.1016/j.ijge.2016.07.003
Abstract: Summary Up to the present, the identification of neurochemical alterations underlying Alzheimer's disease allowed for the development of the first generation of therapies that are somewhat specific for this disorder. Although both cholinesterase inhibitors and… read more here.
Keywords: alzheimer disease; therapeutic targets; targets alzheimer; new therapeutic ... See more keywords