Synthesis of new triazole tethered derivatives of curcumin and their antibacterial and antifungal properties
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-018-1524-7
Abstract: New derivatives of curcumin connected to 1,2,3-triazole ring were synthesized by Knoevenagel reaction of the middle carbon with aromatic aldehydes, followed by alkyne-azide 1,3-dipolar cycloaddition. These new compounds were evaluated for their antimicrobial activity against… read more here.
Keywords: antibacterial antifungal; tethered derivatives; new triazole; synthesis new ... See more keywords
Synthesis and preliminary anticancer evaluation of new triazole bisphosphonate-based isoprenoid biosynthesis inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113241
Abstract: The synthesis of a new set of triazole bisphosphonates 8a-d and 9a-d presenting an alkyl or phenyl substituent at the C-4 or C-5 position of the triazole ring is described. These compounds have been evaluated… read more here.
Keywords: anticancer evaluation; new triazole; biosynthesis; evaluation new ... See more keywords
A new Zn-triazole MOF showing very long-lived luminescence up to 3 s
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Solid State Chemistry"
DOI: 10.1016/j.jssc.2021.122369
Abstract: Abstract A 2D metal-organic framework (MOF) of Zn(CH3COO)2(L) (namely ECUT-137, HL = 3-amino-1,2,4-triazole) was synthesized by hydrothermal reaction of Zn(CH3COO)2 and HL at 180 °C. The Zn(II) ions in ECUT-137 show the common tetrahedral geometry and combined together… read more here.
Keywords: showing long; triazole mof; mof showing; new triazole ... See more keywords
New 1,2,3-Triazole-Appended Bis-pyrazoles: Synthesis, Bioevaluation, and Molecular Docking
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.1c03734
Abstract: The present work describes design of a small library of new 1,2,3-triazole-appended bis-pyrazoles by using a molecular hybridization approach, and the synthesized hybrids were evaluated for their antifungal activity against different fungal strains, namely, Candida… read more here.
Keywords: bis pyrazoles; new triazole; triazole appended; appended bis ... See more keywords
A new 1,2,3-triazole-decorated imino-phenol: selective sensing of Zn2+, Cu2+ and picric acid under different experimental conditions
Sign Up to like & getrecommendations! Published in 2021 at "New Journal of Chemistry"
DOI: 10.1039/d1nj01853a
Abstract: A new 1,2,3-triazole-based imino-phenol 1 is synthesized. It selectively senses Zn2+ in CH3CN–H2O with a detection limit of 1.8 × 10−6 M. Further, the selective sensing of Cu2+ and picric acid is achieved by the… read more here.
Keywords: zn2; imino phenol; selective sensing; cu2 picric ... See more keywords
Microwave-Assisted Regioselective Synthesis and 2D-NMR Studies of New 1,2,3-Triazole Compounds Derived from Acridone
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Chemistry"
DOI: 10.1155/2021/5540173
Abstract: A simple and mild protocol towards the synthesis of new 1,2,3-triazole compounds derived from acridone has been developed via regiospecific 1,3-dipolar cycloaddition reaction between 10-(prop-2-yn-1-yl)acridone derivatives and aromatic azides using CuI as a catalyst. The… read more here.
Keywords: new triazole; microwave assisted; triazole compounds; derived acridone ... See more keywords
Synthesis and molecular docking and of new 1,2,3-triazole carbohydrates with COVID-19 proteins.
Sign Up to like & getrecommendations! Published in 2022 at "Current organic synthesis"
DOI: 10.2174/1570179419666220414095602
Abstract: AIMS With this aim, we have established this paper to recommend a novel way for the preparation of carbohydrates encompassing a 1,2,3-triazole motif that were prepared using an efficient click chemistry synthesis. BACKGROUND The SARS-CoV-2… read more here.
Keywords: molecular docking; new triazole; copper nanoparticles; triazole carbohydrates ... See more keywords
New 1,2,3-Triazole-Coumarin-Glycoside Hybrids and Their 1,2,4-Triazolyl Thioglycoside Analogs Targeting Mitochondria Apoptotic Pathway: Synthesis, Anticancer Activity and Docking Simulation
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27175688
Abstract: Toxicity and resistance to newly synthesized anticancer drugs represent a challenging phenomenon of intensified concern arising from variation in drug targets and consequently the prevalence of the latter concern requires further research. The current research… read more here.
Keywords: new triazole; anticancer activity; synthesis anticancer; coumarin ... See more keywords
Design, Synthesis, and Pharmacology of New Triazole-Containing Quinolinones as CNS Active Agents
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041987
Abstract: Epilepsy and major depressive disorder are the two of the most common central nervous system (CNS) diseases. Clinicians and patients call for new antidepressants, antiseizure medicines, and in particular drugs for depression and epilepsy comorbidities.… read more here.
Keywords: new triazole; active agents; pharmacology; immobility time ... See more keywords
New 1,2,3-Triazole Scaffold Schiff Bases as Potential Anti-COVID-19: Design, Synthesis, DFT-Molecular Docking, and Cytotoxicity Aspects
Sign Up to like & getrecommendations! Published in 2021 at "Vaccines"
DOI: 10.3390/vaccines9091012
Abstract: Schiff bases encompassing a 1,2,3-triazole motif were synthesized using an efficient multi-step synthesis. The formations of targeted Schiff base ligands were confirmed by different spectroscopic techniques (FT-IR, 1H NMR, 13C NMR, and CHN analysis). The… read more here.
Keywords: schiff; schiff bases; new triazole; cytotoxicity ... See more keywords
New triazole-substituted triterpene derivatives exhibiting anti-RSV activity: synthesis, biological evaluation, and molecular modeling
Sign Up to like & getrecommendations! Published in 2022 at "Beilstein Journal of Organic Chemistry"
DOI: 10.3762/bjoc.18.161
Abstract: Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infections in infants. Currently, ribavirin, a nucleoside analog containing a 1,2,4-triazole-3-carboxamide moiety, is a first-line drug for its treatment, however, its clinical… read more here.
Keywords: new triazole; triterpene derivatives; molecular modeling; rsv ... See more keywords