New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies
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DOI: 10.1371/journal.pone.0274081
Abstract: Fifteen quinazoline derivatives were designed and synthesized as DNA intercalators. The cytotoxicity of the designed members was assessed against HCT-116 and HepG2 cancer cell lines. In addition, the topoisomerase II (Topo II) inhibitory effect was… read more here.
Keywords: silico studies; topo inhibitors; new triazolo; triazolo quinazolines ... See more keywords