A new ex vivo skin model for mechanistic understanding of putative anti-inflammatory topical therapeutics.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2022.121610
Abstract: Several in vitro models have been designed as test systems for inflammatory skin conditions, commonly using cell-culture or reconstructed human epidermis approaches. However, these systems poorly recapitulate the physiology and, importantly, the metabolism and biochemical… read more here.
Keywords: vivo skin; model mechanistic; skin model; model ... See more keywords
A new in vivo method to retard progression of intervertebral disc degeneration through stimulation of endogenous stem cells with simvastatin.
Sign Up to like & getrecommendations! Published in 2017 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2017.02.014
Abstract: Degenerative disc disease is a worldwide problem, however, conservative treatment and surgical treatment can only partly relieve symptoms, but do not have therapeutic effect on the degenerated intervertebral disc (IVD) itself. The use of stem… read more here.
Keywords: new vivo; intervertebral disc; nucleus pulposus; stem ... See more keywords
A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24043942
Abstract: Non-alcoholic fatty liver disease (NAFLD), which starts with liver steatosis, is a growing worldwide epidemic responsible for chronic liver diseases. Among its risk factors, exposure to environmental contaminants, such as endocrine disrupting compounds (EDC), has… read more here.
Keywords: steatosis; regulation; liver steatosis; new vivo ... See more keywords