New zebrafish model for monitoring proximal tubule physiology in genetic and acquired renal Fanconi syndromes.
Sign Up to like & getrecommendations! Published in 2020 at "Kidney international"
DOI: 10.1016/j.kint.2020.02.014
Abstract: Inherited and acquired disorders that affect proximal tubule endocytosis and lysosomal processing manifest with improper loss of solutes and proteins. The zebrafish pronephros is conserved with humans and is used to model numerous renal conditions,… read more here.
Keywords: zebrafish model; proximal tubule; model monitoring; physiology ... See more keywords
A New Zebrafish Model to Measure Neuronal α-Synuclein Clearance In Vivo
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13050868
Abstract: The accumulation and aggregation of α-synuclein (α-SYN) is a common characteristic of synucleinopathies, such as Parkinson’s Disease (PD), Dementia with Lewy Bodies (DLB) or Multiple System Atrophy (MSA). Multiplications of the wildtype gene of α-SYN… read more here.
Keywords: clearance; measure neuronal; model measure; synuclein ... See more keywords