The Newborn Fmr1 Knockout Mouse: A Novel Model of Excess Ubiquinone and Closed Mitochondrial Permeability Transition Pore in the Developing Heart
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DOI: 10.1038/s41390-020-1064-6
Abstract: Background Mitochondrial permeability transition pore (mPTP) closure triggers cardiomyocyte differentiation during development while pathological opening causes cell death during myocardial ischemia-reperfusion and heart failure. Ubiquinone modulates the mPTP; however, little is known about its mechanistic… read more here.
Keywords: ubiquinone; heart; fmr1; newborn fmr1 ... See more keywords