Adult newborn neurons interfere with fear discrimination in a protocol‐dependent manner
Sign Up to like & getrecommendations! Published in 2017 at "Brain and Behavior"
DOI: 10.1002/brb3.796
Abstract: Significant enhancement of neurogenesis is known to occur in response to a variety of brain insults such as traumatic brain injury. Previous studies have demonstrated that injury‐induced newborn neurons are required for hippocampus‐dependent spatial learning… read more here.
Keywords: interfere fear; fear discrimination; adult; adult newborn ... See more keywords
Maturation of newborn neurons predicts social memory persistence in mice
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108102
Abstract: Memory transience is essential to gain cognitive flexibility. Recently, hippocampal neurogenesis is emerging as one of the mechanisms involved in the balance between persistence and forgetting. Social recognition memory (SRM) has its duration prolonged by… read more here.
Keywords: maturation newborn; neurogenesis; newborn neurons; neurons predicts ... See more keywords
Altered hippocampal neurogenesis in a mouse model of autism revealed by genetic polymorphisms and by atypical development of newborn neurons
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-53614-y
Abstract: Individuals with autism spectrum disorder (ASD) often exhibit atypical hippocampal anatomy and connectivity throughout their lifespan, potentially linked to alterations in the neurogenic process within the hippocampus. In this study, we performed an in-silico analysis… read more here.
Keywords: neurogenesis; newborn neurons; snps genes; model ... See more keywords
Newborn Neurons Are Damaged In Vitro by a Low Concentration of Silver Nanoparticles Through the Inflammatory Oxidative Stress Pathway.
Sign Up to like & getrecommendations! Published in 2017 at "DNA and cell biology"
DOI: 10.1089/dna.2017.3795
Abstract: With increasing applications of nanomaterials, including silver nanoparticles (AgNPs), unknown potential risks are present against humans and the environment, especially to the fetus and neonates, which are more sensitive to the cytotoxicity of such agents.… read more here.
Keywords: newborn neurons; silver nanoparticles; low concentration; oxidative stress ... See more keywords
Aging impairs dendrite morphogenesis of newborn neurons and is rescued by 7, 8‐dihydroxyflavone
Sign Up to like & getrecommendations! Published in 2017 at "Aging Cell"
DOI: 10.1111/acel.12553
Abstract: All aging individuals will develop some degree of decline in cognitive capacity as time progresses. The molecular and cellular mechanisms leading to age‐related cognitive decline are still not fully understood. Through our previous research, we… read more here.
Keywords: dihydroxyflavone; newborn neurons; development newborn; aging impairs ... See more keywords
Silencing dentate newborn neurons alters excitatory/inhibitory balance and impairs behavioral inhibition and flexibility
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adk4741
Abstract: Adult neurogenesis confers the hippocampus with unparalleled neural plasticity, essential for intricate cognitive functions. The specific influence of sparse newborn neurons (NBNs) in modulating neural activities and subsequently steering behavior, however, remains obscure. Using an… read more here.
Keywords: newborn neurons; silencing dentate; inhibition; flexibility ... See more keywords
Is Adult Hippocampal Neurogenesis Really Relevant for the Treatment of Psychiatric Disorders?
Sign Up to like & getrecommendations! Published in 2020 at "Current Neuropharmacology"
DOI: 10.2174/1570159x18666200818194948
Abstract: Adult neurogenesis consists in the generation of newborn neurons from neural stem cells taking place in the adult brain. In mammals, this process is limited to very few areas of the brain, and one of… read more here.
Keywords: hippocampal neurogenesis; neurogenesis; adult hippocampal; psychiatric disorders ... See more keywords
Intracellular A53T Mutant α-Synuclein Impairs Adult Hippocampal Newborn Neuron Integration
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.561963
Abstract: Dendritic dysfunction is an early event in α-synuclein (α-syn) mediated neurodegeneration. Altered postsynaptic potential and loss of dendritic spines have been observed in different in vitro and in vivo models of synucleinopathies. The integration of… read more here.
Keywords: adult; integration; syn; newborn neurons ... See more keywords
Extent and activity of adult hippocampal neurogenesis
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2025.1709208
Abstract: Our understanding of adult neurogenesis has advanced far since Joseph Altman reported newborn neurons in the adult rodent brain over 60 years ago, but only recently have we been able to directly interrogate its role… read more here.
Keywords: neurogenesis; adult; newborn neurons; extent activity ... See more keywords
Activation of Transient Receptor Potential Vanilloid 4 Impairs the Dendritic Arborization of Newborn Neurons in the Hippocampal Dentate Gyrus through the AMPK and Akt Signaling Pathways
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2017.00190
Abstract: Neurite growth is an important process for the adult hippocampal neurogenesis which is regulated by a specific range of the intracellular free Ca2+ concentration ([Ca2+]i). Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable channel… read more here.
Keywords: arborization newborn; dendritic arborization; newborn neurons; transient receptor ... See more keywords
Regional Patterning of Adult Neurogenesis in the Homing Pigeon’s Brain
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychology"
DOI: 10.3389/fpsyg.2022.889001
Abstract: In the avian brain, adult neurogenesis has been reported in the telencephalon of several species, but the functional significance of this trait is still ambiguous. Homing pigeons (Columba livia f.d.) are well-known for their navigational… read more here.
Keywords: adult newborn; adult; newborn neurons; adult neurogenesis ... See more keywords