Identification and Biological Activity of NFAT-133 Congeners from Streptomyces pactum.
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DOI: 10.1021/acs.jnatprod.1c00152
Abstract: The soil bacterium Streptomyces pactum ATCC 27456 produces a number of polyketide natural products. Among them is NFAT-133, an inhibitor of the nuclear factor of activated T cells (NFAT) that suppresses interleukin-2 (IL-2) expression and… read more here.
Keywords: biological activity; atcc 27456; nfat 133; identification biological ... See more keywords
An efficient stereochemical elucidation of the aromatic polyketide NFAT-133 using the novel NOE quantification combined with nJ H-H and nJ C-H coupling constants.
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DOI: 10.1080/14786419.2025.2570506
Abstract: NFAT-133, which was isolated from Streptomyces sp., is an immunosuppressive and antidiabetic aromatic polyketide containing three contiguous stereocenters. Although its absolute configuration was first proposed mainly based on NMR data, the later study employing the… read more here.
Keywords: aromatic polyketide; noe quantification; novel noe; nfat 133 ... See more keywords