Modulation of TCR-dependent NFAT signaling is impaired in HIV-1 Nef isolates from elite controllers.
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2019.02.008
Abstract: HIV-1 Nef modulates the activation state of CD4+ T cells by altering signaling events elicited by the T cell receptor (TCR). Primary nef sequences exhibit extensive inter-individual diversity that influences their ability to downregulate CD4… read more here.
Keywords: hiv; nfat signaling; elite controllers; hiv nef ... See more keywords
Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-21073-x
Abstract: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and typically fatal lung disease with a very low survival rate. Excess accumulation of fibroblasts, myofibroblasts and extracellular matrix creates hypoxic conditions within the lungs, causing asphyxiation.… read more here.
Keywords: hif; fibroblast proliferation; proliferation; hypoxia induces ... See more keywords