SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1712108
Abstract: ABSTRACT Lipotoxicity, induced by saturated fatty acid (SFA)-mediated cell death, plays an important role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). The KEAP1 (kelch like ECH associated protein 1)-NFE2L2/NRF2 (nuclear factor, erythroid 2… read more here.
Keywords: sqstm1 p62; lipotoxicity; kinase; nfe2l2 nrf2 ... See more keywords
Loss of ubiquitinated protein autophagy is compensated by persistent cnc/NFE2L2/Nrf2 antioxidant responses.
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2037852
Abstract: SQSTM1/p62-type selective macroautophagy/autophagy receptors cross-link poly-ubiquitinated cargo and autophagosomal LC3/Atg8 proteins to deliver them for lysosomal degradation. Consequently, loss of autophagy leads to accumulation of polyubiquitinated protein aggregates that are also frequently seen in various… read more here.
Keywords: cnc nfe2l2; protein autophagy; autophagy; nfe2l2 nrf2 ... See more keywords