LAUSR

Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA.

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1 Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.11.078

Abstract: Notch is activated globally in pancreatic progenitors; however, for progenitors to differentiate into endocrine cells, they must escape Notch activation to express Neurogenin-3. Here, we find that the transcription factor nuclear factor I/A (NFIA) promotes… read more here.

Keywords: notch ligand; cell; cell fate; nfia ... See more keywords

NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program

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1 Published in 2017 at "Nature Cell Biology"

DOI: 10.1038/ncb3590

Abstract: Brown fat dissipates energy as heat and protects against obesity. Here, we identified nuclear factor I-A (NFIA) as a transcriptional regulator of brown fat by a genome-wide open chromatin analysis of murine brown and white… read more here.

Keywords: ppar; fat gene; fat specific; gene program ... See more keywords