Neurofilament light chain and retinal layers' determinants and association: A population‐based study
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51522
Abstract: Both retinal atrophy measured through optical coherence tomography and plasma neurofilament light chain (NfL) levels are markers of neurodegeneration, but their relationship is unknown. Therefore, we assessed their determinants and association in 4369 participants of… read more here.
Keywords: neurofilament light; retinal atrophy; determinants association; population based ... See more keywords
Serum neurofilaments as candidate biomarkers of natalizumab associated progressive multifocal leukoencephalopathy
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25523
Abstract: We read with great interest the article published by Dalla Costa et al concerning the role of serum neurofilament light chains (NfL) as candidate biomarkers of progressive multifocal leukoencephalopathy (PML) during natalizumab treatment (NTZ-PML) in… read more here.
Keywords: nfl levels; pml onset; serum; serum nfl ... See more keywords
Neurological symptoms and neuronal damage markers in acute COVID‐19: Is there a correlation? A pilot study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28240
Abstract: A wide spectrum of neurological symptoms (NS) has been described in patients with COVID‐19. We examined the plasma levels of neuron‐specific enolase (NSE) and neurofilament light chain (NFL) together, as neuronal damage markers, and their… read more here.
Keywords: neurological symptoms; neuronal damage; acute covid; nfl levels ... See more keywords
NFL during acute spinal cord lesions in MS: a hurdle for the detection of inflammatory activity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurology"
DOI: 10.1007/s00415-021-10926-7
Abstract: Levels of neuro-filament light chain (NFL) correlate with clinical and radiological activity in multiple sclerosis (MS) and have been used as a surrogate biomarker of axonal destruction related to inflammatory activity. The main objective of… read more here.
Keywords: inflammatory activity; cord; spinal cord; nfl levels ... See more keywords
Plasma neurofilament light chain as a biomarker of Alzheimer’s disease in Subjective Cognitive Decline and Mild Cognitive Impairment
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurology"
DOI: 10.1007/s00415-022-11055-5
Abstract: Neurofilament light chain (NfL) is becoming increasingly notable in neurological diseases including AD, and it has been suggested as a new peripherical biomarker of neurodegeneration. We aimed to compare plasma NfL levels among Subjective Cognitive… read more here.
Keywords: biomarker; cognitive decline; cognitive impairment; nfl levels ... See more keywords
NfL levels predominantly increase at disease onset in MOG-Abs-associated disorders.
Sign Up to like & getrecommendations! Published in 2021 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2021.102833
Abstract: The unpredictable course and uncertain impact of relapses make treatment strategies of anti-myelin oligodendrocyte glycoprotein antibodies associated disorders (MOGAD) challenging. We analysed neurofilament light chain levels (NfL) in onset and follow-up sera of 18 patients… read more here.
Keywords: nfl levels; disease onset; levels predominantly; disorders nfl ... See more keywords
Neurofilament light chain - a possible fluid biomarker in the intrahippocampal kainic acid mouse model for chronic epilepsy?
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia"
DOI: 10.1111/epi.17669
Abstract: OBJECTIVE In the management of epilepsy, there is an ongoing quest to discover new biomarkers to improve the diagnostic process, the monitoring of disease progression, and the evaluation of treatment responsiveness. In this regard, biochemical… read more here.
Keywords: chronic epilepsy; kainic acid; fluid biomarker; nfl levels ... See more keywords
Serum neurofilament light is sensitive to active cerebral small vessel disease
Sign Up to like & getrecommendations! Published in 2017 at "Neurology"
DOI: 10.1212/wnl.0000000000004645
Abstract: Objective: To explore whether serum neurofilament light chain protein (NfL) levels are increased in patients with MRI-confirmed recent small subcortical infarcts (RSSI) compared to healthy controls and to determine the subsequent course and determinants of… read more here.
Keywords: nfl levels; neurofilament light; cerebral small; small vessel ... See more keywords
Blood neurofilament light chain as a biomarker of MS disease activity and treatment response
Sign Up to like & getrecommendations! Published in 2019 at "Neurology"
DOI: 10.1212/wnl.0000000000007032
Abstract: Objective To assess the value of blood neurofilament light chain (NfL) as a biomarker of recent, ongoing, and future disease activity and tissue damage and its utility to monitor treatment response in relapsing-remitting multiple sclerosis.… read more here.
Keywords: disease activity; blood; biomarker; nfl levels ... See more keywords
Association Between EEG Patterns and Serum Neurofilament Light After Cardiac Arrest
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DOI: 10.1212/wnl.0000000000200335
Abstract: Background and Objectives EEG is widely used for prediction of neurologic outcome after cardiac arrest. To better understand the relationship between EEG and neuronal injury, we explored the association between EEG and neurofilament light (NfL)… read more here.
Keywords: background; eeg patterns; nfl levels; eeg ... See more keywords
Longitudinal Changes in Cognitive Functioning and Brain Structure in Professional Boxers and Mixed Martial Artists After They Stop Fighting
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DOI: 10.1212/wnl.0000000000201158
Abstract: Background and Objectives This study compares longitudinal changes in cognitive functioning and brain structures in male fighters who transitioned to an inactive fighting status without any further exposure to repetitive head impacts (RHIs) and fighters… read more here.
Keywords: boxers mixed; active fighters; brain; cognitive functioning ... See more keywords