Neurofilament light chain and retinal layers' determinants and association: A population‐based study
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51522
Abstract: Both retinal atrophy measured through optical coherence tomography and plasma neurofilament light chain (NfL) levels are markers of neurodegeneration, but their relationship is unknown. Therefore, we assessed their determinants and association in 4369 participants of… read more here.
Keywords: neurofilament light; retinal atrophy; determinants association; population based ... See more keywords
Serum neurofilaments as candidate biomarkers of natalizumab associated progressive multifocal leukoencephalopathy
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25523
Abstract: We read with great interest the article published by Dalla Costa et al concerning the role of serum neurofilament light chains (NfL) as candidate biomarkers of progressive multifocal leukoencephalopathy (PML) during natalizumab treatment (NTZ-PML) in… read more here.
Keywords: nfl levels; pml onset; serum; serum nfl ... See more keywords
Neurological symptoms and neuronal damage markers in acute COVID‐19: Is there a correlation? A pilot study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28240
Abstract: A wide spectrum of neurological symptoms (NS) has been described in patients with COVID‐19. We examined the plasma levels of neuron‐specific enolase (NSE) and neurofilament light chain (NFL) together, as neuronal damage markers, and their… read more here.
Keywords: neurological symptoms; neuronal damage; acute covid; nfl levels ... See more keywords
NFL during acute spinal cord lesions in MS: a hurdle for the detection of inflammatory activity
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurology"
DOI: 10.1007/s00415-021-10926-7
Abstract: Levels of neuro-filament light chain (NFL) correlate with clinical and radiological activity in multiple sclerosis (MS) and have been used as a surrogate biomarker of axonal destruction related to inflammatory activity. The main objective of… read more here.
Keywords: inflammatory activity; cord; spinal cord; nfl levels ... See more keywords
Plasma neurofilament light chain as a biomarker of Alzheimer’s disease in Subjective Cognitive Decline and Mild Cognitive Impairment
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neurology"
DOI: 10.1007/s00415-022-11055-5
Abstract: Neurofilament light chain (NfL) is becoming increasingly notable in neurological diseases including AD, and it has been suggested as a new peripherical biomarker of neurodegeneration. We aimed to compare plasma NfL levels among Subjective Cognitive… read more here.
Keywords: biomarker; cognitive decline; cognitive impairment; nfl levels ... See more keywords
Neuroaxonal Injury May Mediate the Association Between Hyperglycemia and Prognosis in Spontaneous Subarachnoid Hemorrhage
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Neurobiology"
DOI: 10.1007/s12035-024-04347-6
Abstract: Hyperglycemia during early brain injury (EBI) period after spontaneous subarachnoid hemorrhage (SAH) is associated with poor outcome, but the underlying physiopathology is unknown. This study assessed if hyperglycemia during EBI is associated with markers of… read more here.
Keywords: clinical outcome; outcome; injury; association ... See more keywords
NfL levels predominantly increase at disease onset in MOG-Abs-associated disorders.
Sign Up to like & getrecommendations! Published in 2021 at "Multiple sclerosis and related disorders"
DOI: 10.1016/j.msard.2021.102833
Abstract: The unpredictable course and uncertain impact of relapses make treatment strategies of anti-myelin oligodendrocyte glycoprotein antibodies associated disorders (MOGAD) challenging. We analysed neurofilament light chain levels (NfL) in onset and follow-up sera of 18 patients… read more here.
Keywords: nfl levels; disease onset; levels predominantly; disorders nfl ... See more keywords
Neurofilament light chain - a possible fluid biomarker in the intrahippocampal kainic acid mouse model for chronic epilepsy?
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia"
DOI: 10.1111/epi.17669
Abstract: OBJECTIVE In the management of epilepsy, there is an ongoing quest to discover new biomarkers to improve the diagnostic process, the monitoring of disease progression, and the evaluation of treatment responsiveness. In this regard, biochemical… read more here.
Keywords: chronic epilepsy; kainic acid; fluid biomarker; nfl levels ... See more keywords
Neurofilament light chain levels as an early predictive biomarker of neurotoxicity after CAR T-cell therapy
Sign Up to like & getrecommendations! Published in 2024 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2024-009525
Abstract: Immune effector cell-associated neurotoxicity syndrome (ICANS) remains a significant cause of morbidity associated with CD19-targeted chimeric antigen receptor (CAR) T-cell therapy. Early prediction of patients who will develop ICANS would be crucial to better guide… read more here.
Keywords: cell therapy; time; car cell; car ... See more keywords
Serum GFAP and NfL levels in migraine: A registry for migraine (REFORM) study
Sign Up to like & getrecommendations! Published in 2025 at "Cephalalgia"
DOI: 10.1177/03331024251338178
Abstract: Objective To determine whether serum glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) concentrations differ between adults with migraine and healthy controls. Methods This single-center, cross-sectional study was conducted from September 2020 to… read more here.
Keywords: nfl concentrations; migraine; gfap nfl; nfl levels ... See more keywords
The potential use of plasma NfL as a diagnostic and prognostic biomarker of fatigue in early Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2025 at "Therapeutic Advances in Neurological Disorders"
DOI: 10.1177/17562864251324406
Abstract: Background: Fatigue is a prevalent non-motor symptom that often appears in the early stages of Parkinson’s disease (PD). Plasma neurofilament light chain (NfL) was elevated in PD patients and may be considered a potential biomarker… read more here.
Keywords: fatigue; plasma nfl; nfl levels; biomarker ... See more keywords