The carcinogen cadmium elevates CpG-demethylation and enrichment of NFYA and E2F1 in the promoter of oncogenic PRMT5 and EZH2 methyltransferases resulting in their elevated expression in vitro.
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DOI: 10.1016/j.chemosphere.2019.125186
Abstract: Cadmium (Cd) is considered as a carcinogenic chemical with potential to endanger normal cellular functioning. The present study was aimed to investigate the impact of Cd on the expression of two oncogenic epigenetic regulators, viz.,… read more here.
Keywords: prmt5 ezh2; prmt5; expression; nfya e2f1 ... See more keywords