NG2 expression in NG2 glia is regulated by binding of SoxE and bHLH transcription factors to a Cspg4 intronic enhancer
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DOI: 10.1002/glia.23521
Abstract: NG2 is a type 1 integral membrane glycoprotein encoded by the Cspg4 gene. It is expressed on glial progenitor cells known as NG2 glial cells or oligodendrocyte precursor cells that exist widely throughout the developing… read more here.
Keywords: transcription; cspg4 gene; ng2 glia; ng2 ... See more keywords
Transient astrocyte‐like NG2 glia subpopulation emerges solely following permanent brain ischemia
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DOI: 10.1002/glia.24064
Abstract: NG2 glia display wide proliferation and differentiation potential under physiological and pathological conditions. Here, we examined these two features following different types of brain disorders such as focal cerebral ischemia (FCI), cortical stab wound (SW),… read more here.
Keywords: astrocyte like; like ng2; ng2 glia; subpopulation ... See more keywords
Separate optogenetic manipulation of Nerve/glial antigen 2 (NG2) glia and mural cells using the NG2 promoter
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DOI: 10.1002/glia.24273
Abstract: Nerve/glial antigen 2 (NG2) is a protein marker of NG2 glia and mural cells, and NG2 promoter activity is utilized to target these cells. However, the NG2 promoter cannot target NG2 glia and mural cells… read more here.
Keywords: ng2 promoter; tta; mural cells; ng2 glia ... See more keywords
The cortical NG2‐glia response to traumatic brain injury
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DOI: 10.1002/glia.24342
Abstract: Traumatic brain injury (TBI) is a significant worldwide cause of morbidity and mortality. A chronic neurologic disease bearing the moniker of “the silent epidemic,” TBI currently has no targeted therapies to ameliorate cellular loss or… read more here.
Keywords: traumatic brain; cortical ng2; tbi; ng2 glia ... See more keywords
Analysis of the GPR17 receptor in NG2‐glia under physiological conditions unravels a new subset of oligodendrocyte progenitor cells with distinct functions
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DOI: 10.1002/glia.24356
Abstract: NG2‐glia comprise a heterogeneous population of cycling cells that give rise to mature, myelinating oligodendrocytes. The mechanisms that regulate the process of differentiation from NG2‐glia into oligodendrocytes are still not fully understood but over the… read more here.
Keywords: gpr17; physiological conditions; gpr17 receptor; ng2 glia ... See more keywords
Glutaredoxin 2 promotes SP-1-dependent CSPG4 transcription and migration of wound healing NG2 glia and glioma cells: Enzymatic Taoism.
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DOI: 10.1016/j.redox.2021.102221
Abstract: Redox regulation of specific cysteines via oxidoreductases of the thioredoxin family is increasingly being recognized as an important signaling pathway. Here, we demonstrate that the cytosolic isoform of the vertebrate-specific oxidoreductase Glutaredoxin 2 (Grx2c) regulates… read more here.
Keywords: migration wound; enzymatic taoism; transcription; wound healing ... See more keywords
NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety
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DOI: 10.1038/s41467-021-25956-y
Abstract: NG2 glia, also known as oligodendrocyte precursor cells (OPCs), play an important role in proliferation and give rise to myelinating oligodendrocytes during early brain development. In contrast to other glial cell types, the most intriguing… read more here.
Keywords: gaba release; ng2 glia; derived gaba; glia derived ... See more keywords
Morphological characterization of NG2 glia and their association with neuroglial cells in the 3-nitropropionic acid–lesioned striatum of rat
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DOI: 10.1038/s41598-018-24385-0
Abstract: Our aim was to examine the spatiotemporal profiles and phenotypic characteristics of neuron-glia antigen 2 (NG2) glia and their associations with neuroglial cells in striatal lesions due to the mitochondrial toxin 3-nitropropionic acid (3-NP). In… read more here.
Keywords: lesion core; ng2 glia; neuroglial cells; lesion ... See more keywords
Kir4.1 channels in NG2-glia play a role in development, potassium signaling, and ischemia-related myelin loss
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DOI: 10.1038/s42003-018-0083-x
Abstract: The contribution of the inwardly rectifying K+ channel subtype Kir4.1 has been focused mainly on astrocytes, where they play important roles in the maintenance of resting membrane potential, extracellular K+ uptake, and facilitation of glutamate… read more here.
Keywords: kir4 channels; channels ng2; ng2 glia; development potassium ... See more keywords
L-Type Ca2+ Channels of NG2 Glia Determine Proliferation and NMDA Receptor-Dependent Plasticity
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DOI: 10.3389/fcell.2021.759477
Abstract: NG2 (nerve/glial antigen 2) glia are uniformly distributed in the gray and white matter of the central nervous system (CNS). They are the major proliferating cells in the brain and can differentiate into oligodendrocytes. NG2… read more here.
Keywords: ng2 glia; proliferation; cav1; type vgccs ... See more keywords