Integrin αvβ3 and disulfide bonds play important roles in NGR-retargeted adenovirus transduction efficiency.
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DOI: 10.1016/j.lfs.2021.120116
Abstract: AIMS Adenoviruses that have CNGRCVSGCAGRC peptide inserted into fiber (AdFNGR) or hexon (AdHNGR) protein, respectively, showed increased transduction of endothelial cells. In this study we investigated if cysteines within the CNGRCVSGCAGRC sequence inserted into Ad5… read more here.
Keywords: disulfide bonds; transduction efficiency; adfngr adhngr; ngr retargeted ... See more keywords