NGS-analysis to the rescue: dual checkpoint inhibition in metastatic osteosarcoma – a case report and review of the literature
Sign Up to like & getrecommendations! Published in 2019 at "Acta Clinica Belgica"
DOI: 10.1080/17843286.2019.1683129
Abstract: ABSTRACT Background: The prognosis and treatment of metastatic osteosarcoma have not changed in the last decades and the responses to chemotherapy in this setting are disappointing. In the past years, immunotherapy has found its place… read more here.
Keywords: literature; metastatic osteosarcoma; treatment; case ... See more keywords
DNAscan: personal computer compatible NGS analysis, annotation and visualisation
Sign Up to like & getrecommendations! Published in 2019 at "BMC Bioinformatics"
DOI: 10.1186/s12859-019-2791-8
Abstract: BackgroundNext Generation Sequencing (NGS) is a commonly used technology for studying the genetic basis of biological processes and it underpins the aspirations of precision medicine. However, there are significant challenges when dealing with NGS data.… read more here.
Keywords: medicine; pipeline; visualisation; analysis ... See more keywords
Germline and somatic variants in ovarian carcinoma: A next-generation sequencing (NGS) analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1030786
Abstract: Background Germline BRCA1/2 mutations are identified in 13-15% of ovarian cancers, while an additional 5-7% of ovarian cancers harbor somatic BRCA1/2 mutations. Beyond these mutations, germline or somatic aberrations in genes of the homologous recombination… read more here.
Keywords: germline; ngs analysis; next generation; sequencing ngs ... See more keywords