Considerations of developing an NGS assay for clinical applications in precision oncology: The NCI-MATCH NGS assay experience.
Sign Up to like & getrecommendations! Published in 2017 at "Current problems in cancer"
DOI: 10.1016/j.currproblcancer.2017.05.003
Abstract: Next generation sequencing (NGS) technologies have been widely adapted in clinical oncology by utilizing the profiled genetic mutation information to select patients and to guide the choice of target therapy. To fulfill the regulatory compliance,… read more here.
Keywords: nci match; ngs assay; precision oncology; oncology ... See more keywords
Baseline VDJ clonotype detection using a targeted sequencing NGS assay: allowing for subsequent MRD assessment
Sign Up to like & getrecommendations! Published in 2020 at "Blood Cancer Journal"
DOI: 10.1038/s41408-020-00343-w
Abstract: Dear Editor, Fluorescent in situ hybridization (FISH), metaphase cytogenetics, and single nucleotide polymorphism (SNP) microarray have long been the standard assays for disease diagnostics and subtyping of multiple myeloma. With the advent of next generation… read more here.
Keywords: ngs assay; myeloma; mrd; sequencing ngs ... See more keywords
High-Throughput Nucleotide Resolution Predictions of Assay Limitations Increase the Reliability and Concordance of Clinical Tests.
Sign Up to like & getrecommendations! Published in 2021 at "JCO clinical cancer informatics"
DOI: 10.1200/cci.21.00057
Abstract: PURPOSE The ability of next-generation sequencing (NGS) assays to interrogate thousands of genomic loci has revolutionized genetic testing. However, translation to the clinic is impeded by false-negative results that pose a risk to patients. In… read more here.
Keywords: ngs assay; concordance; approach; high throughput ... See more keywords
Next Generation Sequencing is a Reliable Tool for Detecting BRCA1/2 Mutations, Including Large Genomic Rearrangements.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical laboratory"
DOI: 10.7754/clin.lab.2021.210609
Abstract: BACKGROUND Next-generation sequencing (NGS) has been implemented as a rapid and cost-effective BRCA1/2 test strategy. The Oncomine™ BRCA Research Assay is an NGS-based tool for simultaneous detection of small-scale mutations and large genomic rearrangements (LGRs).… read more here.
Keywords: ngs assay; large genomic; genomic rearrangements; next generation ... See more keywords