Synthesis of Indolizines via Reaction of 2-Substitued Azaarenes with Enals by an Amine-NHC Relay Catalysis.
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DOI: 10.1021/acs.orglett.7b00566
Abstract: A metal-free catalytic strategy for the facile synthesis of biologically relevant molecular architectures indolizines and imidazopyridines has been developed. The process is promoted by amine and N-heterocyclic carbene (NHC) relay catalysis via Michael addition-[3 +… read more here.
Keywords: nhc relay; synthesis indolizines; indolizines via; relay catalysis ... See more keywords