TBX20 inhibits colorectal cancer tumorigenesis by impairing NHEJ-mediated DNA repair.
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DOI: 10.1111/cas.15348
Abstract: DNA high methylation is one of driving force for colorectal carcinoma (CRC) pathogenesis. Transcription factors (TFs) can determine cell fate and play fundamental roles in multistep process of tumorigenesis. Dysregulation of DNA methylation of TFs… read more here.
Keywords: dna; dna repair; nhej mediated; crc ... See more keywords
Abstract 3218: Maternal embryonic leucine zipper kinase (MELK) confers radioresistance in triple-negative breast cancers (TNBC) through a nonhomologous end joining (NHEJ)-mediated pathway
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DOI: 10.1158/1538-7445.am2018-3218
Abstract: Background: Increased rates of locoregional recurrence have been observed in TNBC despite the use of radiation (RT); therefore, approaches that result in radiosensitizaton in TNBC may improve clinical outcomes. Despite some controversy as to the… read more here.
Keywords: nhej mediated; melk; kinase; melk confers ... See more keywords