Discovery of a Novel Oral Proteasome Inhibitor to Block NLRP3 Inflammasome Activation with Anti-inflammation Activity.
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DOI: 10.1021/acs.jmedchem.2c00523
Abstract: NLRP3 inflammasome activation plays a critical role in inflammation-related disorders. More small-molecule entities are needed to study the mechanism of NLRP3 inflammasome activation and to validate the efficacy and safety of the NLRP3 pathway. Herein,… read more here.
Keywords: inflammation; proteasome inhibitor; inflammasome activation; nlrp3 inflammasome ... See more keywords