Abnormal mechanical stress on bicuspid aortic valve induces valvular calcification and inhibits Notch1/NICD/Runx2 signal
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DOI: 10.7717/peerj.14950
Abstract: Background Bicuspid aortic valve (BAV) is a congenital cardiac deformity, increasing the risk of developing calcific aortic valve disease (CAVD). The disturbance of hemodynamics can induce valvular calcification, but the mechanism has not been fully… read more here.
Keywords: aortic valve; mechanical stress; valve; valvular calcification ... See more keywords