Abstract 4644: Modeling the effects of niche specific microenvironmental changes on patient-derived organoids
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4644
Abstract: Here, we present an approach to study the effects of microenvironmental changes on inter- and intratumoral heterogeneity using colorectal cancer (CRC) patient-derived organoids. We identified relevant paracrine interactions between stromal and tumor cells based on… read more here.
Keywords: microenvironmental changes; niche specific; derived organoids; colorectal cancer ... See more keywords
CXCL12 Has Niche-Specific Roles in Leukemia Stem Cell Function.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2019-044
Abstract: MSC-expressed CXCL12 promotes LSC quiescence and promotes BCR-ABL inhibitor resistance. read more here.
Keywords: niche specific; specific roles; cxcl12 niche; roles leukemia ... See more keywords