Nickel/Briphos-Catalyzed Direct Transamidation of Unactivated Secondary Amides Using Trimethylsilyl Chloride.
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DOI: 10.1021/acs.orglett.8b03304
Abstract: Direct transamidation of secondary amides was developed via nickel catalysis. In the presence of trimethylsilyl chloride and manganese, Ni(diglyme)Cl2 with a Briphos ligand efficiently promoted the transamidation of N-aryl benzamide derivatives with primary amines to… read more here.
Keywords: nickel briphos; trimethylsilyl chloride; secondary amides; direct transamidation ... See more keywords