Enantioselective Synthesis of N-Benzylic Heterocycles: A Nickel and Photoredox Dual Catalysis Approach.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03338
Abstract: Reported herein is a dual nickel- and photoredox-catalyzed modular approach for the preparation of enantioenriched N-benzylic heterocycles. α-Heterocyclic carboxylic acids, easily obtainable from common commercial material, are reported as suitable substrates for a decarboxylative strategy… read more here.
Keywords: heterocycles nickel; nickel photoredox; synthesis benzylic; approach ... See more keywords
Dual Nickel/Photoredox-Catalyzed Asymmetric Carbosulfonylation of Alkenes.
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DOI: 10.1021/jacs.3c00744
Abstract: An asymmetric three-component carbosulfonylation of alkenes is presented here. The reaction, involving the simultaneous formation of a C-C and a C-S bond across the π-system, uses a dual nickel/photoredox catalytic system to produce both β-aryl… read more here.
Keywords: carbosulfonylation alkenes; catalyzed asymmetric; photoredox catalyzed; nickel photoredox ... See more keywords
Regiodivergent sulfonylarylation of 1,3-enynes via nickel/photoredox dual catalysis
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DOI: 10.1039/d1sc04320j
Abstract: Catalytic difunctionalization of 1,3-enynes represents an efficient and versatile approach to rapidly assemble multifunctional propargylic compounds, allenes and 1,3-dienes. Controlling selectivity in such addition reactions has been a long-standing challenging task due to multiple reactive… read more here.
Keywords: sulfonylarylation enynes; catalysis; regiodivergent sulfonylarylation; sulfonylarylation ... See more keywords
Three-component reductive conjugate addition/aldol tandem reaction enabled by nickel/photoredox dual catalysis
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DOI: 10.1039/d2sc06303d
Abstract: A three-component reductive cross-coupling of aryl halides, aldehydes, and alkenes by nickel/photoredox dual catalysis is disclosed. The key to success for this tandem transformation is to identify α-silylamine as a unique organic reductant, which releases… read more here.
Keywords: conjugate addition; component reductive; dual catalysis; photoredox dual ... See more keywords