Nicotinamide adenine dinucleotide metabolism: driving or counterbalancing inflammatory bowel disease?
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14528
Abstract: Nicotinamide adenine dinucleotide (NAD) is an important electron and hydrogen carrier for oxidative metabolism and involved in energy production, antioxidant responses, and signal transduction within cells. NAD‐consuming enzymes can mediate post‐translational modifications, such as deacylation… read more here.
Keywords: metabolism; nicotinamide adenine; adenine dinucleotide; inflammatory bowel ... See more keywords
Activation of nicotinamide adenine dinucleotide phosphate oxidase is the primary trigger of epileptic seizures in rodent models
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Neurology"
DOI: 10.1002/ana.25474
Abstract: Despite decades of epilepsy research, 30% of focal epilepsies remain resistant to antiseizure drugs, with effective drug development impeded by lack of understanding on how seizures are initiated. Here, we report the mechanism of seizure… read more here.
Keywords: adenine dinucleotide; nicotinamide adenine; dinucleotide phosphate; phosphate oxidase ... See more keywords
Viewing teratogens through the lens of nicotinamide adenine dinucleotide (NAD+)
Sign Up to like & getrecommendations! Published in 2022 at "Birth Defects Research"
DOI: 10.1002/bdr2.2089
Abstract: Nicotinamide adenine dinucleotide (NAD+) depletion is associated with numerous diseases in humans. Recently it was revealed that genetic blockage of the NAD+ synthesis pathway in humans causes birth defects in multiple organ systems and miscarriage.… read more here.
Keywords: nicotinamide adenine; adenine dinucleotide; lens nicotinamide; viewing teratogens ... See more keywords
Nicotinamide Adenine Dinucleotide Supplementation in Parkinson's Disease: A Potential Disease‐Modifying Agent Targeting Multiple Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Movement Disorders Clinical Practice"
DOI: 10.1002/mdc3.13500
Abstract: modi fi cation and neuroprotection are still unmet needs in Parkinson ’ s disease (PD), due to several challenges, including multiple pathogenic the upregulation of genes involved in proteasomal function, mitochondrial homeostasis, and antioxidant function.… read more here.
Keywords: supplementation; nicotinamide adenine; adenine dinucleotide; disease ... See more keywords
Nicotinamide adenine dinucleotide emerges as a therapeutic target in aging and ischemic conditions
Sign Up to like & getrecommendations! Published in 2019 at "Biogerontology"
DOI: 10.1007/s10522-019-09805-6
Abstract: Nicotinamide adenine dinucleotide (NAD+) has been described as central coenzyme of redox reactions and is a key regulator of stress resistance and longevity. Aging is a multifactorial and irreversible process that is characterized by a… read more here.
Keywords: adenine dinucleotide; emerges therapeutic; ischemic conditions; nicotinamide adenine ... See more keywords
Ethanol Biofuel Cell Utilizing Photo-Excited Flavin-Mediated Oxidation of β-Nicotinamide Adenine Dinucleotide Hydrate (NADH) at the Anode and Reduction of H+ Ions at the Cathode
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Electronic Materials"
DOI: 10.1007/s11664-020-08189-5
Abstract: At the anode, the electrochemical oxidation of β-nicotinamide adenine dinucleotide hydrate (NADH) to its oxidized form (NAD+) spontaneously proceeded using photo-excited flavin mononucleotide (FMN) as the redox mediator. At the cathode, H+ ions were electroreduced… read more here.
Keywords: adenine dinucleotide; biofuel; nicotinamide adenine; oxidation nicotinamide ... See more keywords
5′ End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.02.019
Abstract: Eukaryotic mRNAs generally possess a 5' end N7 methyl guanosine (m7G) cap that promotes their translation and stability. However, mammalian mRNAs can also carry a 5' end nicotinamide adenine dinucleotide (NAD+) cap that, in contrast to the… read more here.
Keywords: decay; nicotinamide adenine; dxo; end nicotinamide ... See more keywords
Simultaneous quantitation of nicotinamide riboside, nicotinamide mononucleotide and nicotinamide adenine dinucleotide in milk by a novel enzyme-coupled assay.
Sign Up to like & getrecommendations! Published in 2017 at "Food chemistry"
DOI: 10.1016/j.foodchem.2016.10.032
Abstract: Nicotinamide riboside, the most recently discovered form of vitamin B3, and its phosphorylated form nicotinamide mononucleotide, have been shown to be potent supplements boosting intracellular nicotinamide adenine dinucleotide (NAD) levels, thus preventing or ameliorating metabolic… read more here.
Keywords: milk; adenine dinucleotide; nicotinamide mononucleotide; nicotinamide adenine ... See more keywords
Nicotinamide adenine dinucleotide treatment alleviates the symptoms of experimental autoimmune encephalomyelitis by activating autophagy and inhibiting the NLRP3 inflammasome.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107092
Abstract: Nicotinamide adenine dinucleotide (NAD + ) is an essential cofactor in numerous metabolic pathways, and so may support protective and reparative processes against central nervous system diseases such as multiple sclerosis (MS). Here, we investigated the therapeutic… read more here.
Keywords: adenine dinucleotide; nicotinamide adenine; treatment; autoimmune encephalomyelitis ... See more keywords
Discovery of Nicotinamide Adenine Dinucleotide Binding Proteins in the Escherichia coli Proteome Using a Combined Energetic- and Structural-Bioinformatics-Based Approach.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.6b00624
Abstract: Protein-ligand interaction plays a critical role in regulating the biochemical functions of proteins. Discovering protein targets for ligands is vital to new drug development. Here, we present a strategy that combines experimental and computational approaches… read more here.
Keywords: adenine dinucleotide; proteins escherichia; nicotinamide adenine; binding proteins ... See more keywords
Mimic of the Cellular Antioxidant Defense System for a Sustainable Regeneration of Nicotinamide Adenine Dinucleotide (NAD)
Sign Up to like & getrecommendations! Published in 2020 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.0c05588
Abstract: The prolonged use of enzymes under oxidative stress is a major challenge in enabling effective enzymatic reaction pathways. Herein, we report a biomimetic antioxidant defensive strategy capable of providing adequate protection of enzymes against superoxide-mediated… read more here.
Keywords: adenine dinucleotide; cellular antioxidant; nicotinamide adenine; regeneration ... See more keywords