Synthesis, computational predictions of selective bioactive nicotinamide derivatives and in vitro biological evaluations
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.06.048
Abstract: Abstract A series of nicotinamide derivatives were designed and studied in silico molecular docking predictions against inflammatory responsible enzymes (cyclooxygenase-1(1PGG) and cyclooxygenase-2 (4-COX)). The well-predicted compounds were synthesized, characterized by the spectroscopic techniques namely, Proton… read more here.
Keywords: predictions selective; nicotinamide derivatives; synthesis computational; vitro biological ... See more keywords
Design, Synthesis and Fungicidal Activity of N-(thiophen-2-yl) Nicotinamide Derivatives
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DOI: 10.3390/molecules27248700
Abstract: Based on the modification of natural products and the active substructure splicing method, a series of new N-(thiophen-2-yl) nicotinamide derivatives were designed and synthesized by splicing the nitrogen-containing heterocycle natural molecule nicotinic acid and the… read more here.
Keywords: design synthesis; thiophen nicotinamide; synthesis fungicidal; nicotinamide derivatives ... See more keywords
Design, Synthesis and Structure-Activity Relationship Studies of Nicotinamide Derivatives as Potent Antifungal Agents by Disrupting Cell Wall
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DOI: 10.3390/molecules28031135
Abstract: Fungal infections pose a serious challenge to human health due to the limited paucity of antifungal treatments. Starting as a hit compound screened from our compound library, a series of nicotinamide derivatives have been successfully… read more here.
Keywords: cell wall; compound; activity; nicotinamide derivatives ... See more keywords