Nicotinamide N-methyltransferase is related to MELF pattern invasion in endometrioid carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer medicine"
DOI: 10.1002/cam4.4359
Abstract: Grade 1 (G1) endometrioid carcinoma (EC) is relatively a good prognosis. However, in a minority of cases, G1 shows an aggressive histological pattern known as the microcystic, elongated, and fragmented (MELF) pattern. We previously reported that… read more here.
Keywords: endometrioid carcinoma; invasion; related melf; nicotinamide methyltransferase ... See more keywords
Glucose availability regulates nicotinamide N-methyltransferase expression in adipocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117474
Abstract: BACKGROUND/OBJECTIVES Nicotinamide N-methyltransferase (NNMT) is a novel regulator of energy homeostasis in adipocytes. NNMT expression in adipose tissue is increased in obesity and diabetes. Knockdown of NNMT prevents mice from developing diet-induced obesity, which is… read more here.
Keywords: availability regulates; nnmt expression; expression; glucose availability ... See more keywords
Potent Uncompetitive Inhibitors of Nicotinamide N-Methyltransferase (NNMT) as In Vivo Chemical Probes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01166
Abstract: NNMT uses SAM as a cofactor to catalyze the methylation of nicotinamide, producing 1-methylnicotinamide. Recent studies have shown that NNMT upregulation in cancer-associated fibroblasts (CAFs) is required to maintain the CAF phenotype in high-grade serous… read more here.
Keywords: potent uncompetitive; chemical probes; uncompetitive inhibitors; nicotinamide methyltransferase ... See more keywords
Bisubstrate Inhibitors of Nicotinamide N-Methyltransferase (NNMT) with Enhanced Activity
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.9b00413
Abstract: Nicotinamide N-methyltransferase (NNMT) catalyzes the methylation of nicotinamide to form N-methylnicotinamide. Overexpression of NNMT is associated with a variety of diseases, including a number of cancers and metabolic disorders, suggesting a role for NNMT as… read more here.
Keywords: bisubstrate; nicotinamide methyltransferase; activity; methyltransferase nnmt ... See more keywords
Tumor stromal nicotinamide N-methyltransferase overexpression as a prognostic biomarker for poor clinical outcome in early-stage colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-06772-w
Abstract: In a quest for prognostic biomarkers in early-stage colorectal cancer, we investigated NNMT (nicotinamide N-methyltransferase) in large cohorts of patients. Immunohistochemical examination of 679 patients illustrates that NNMT protein is predominantly expressed in the cancer… read more here.
Keywords: cancer; stage colorectal; nicotinamide methyltransferase; stage ... See more keywords
Effect of nicotinamide N-methyltransferase on lipid accumulation in 3T3-L1 adipocytes
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2074768
Abstract: ABSTRACT Nicotinamide N-methyltransferase (NNMT) is a methylase, and its expression is positively correlated with obesity and insulin resistance. This study aims to detect the effects of NNMT on lipid accumulation, triglyceride content, adipocyte differentiation-related transcription… read more here.
Keywords: transcription; nicotinamide methyltransferase; lipid accumulation; expression ... See more keywords
Nicotinamide N-methyltransferase: potential involvement in cutaneous malignant melanoma
Sign Up to like & getrecommendations! Published in 2018 at "Melanoma Research"
DOI: 10.1097/cmr.0000000000000430
Abstract: Nicotinamide N-methyltransferase (NNMT) is an enzyme that catalyzes the N-methylation of nicotinamide and pyridine compounds, participating in xenobiotic and drug metabolism. Data on literature have evidenced a possible role of NNMT in many solid cancers,… read more here.
Keywords: melanoma; methyltransferase potential; potential involvement; involvement cutaneous ... See more keywords
Nicotinamide N-methyltransferase promotes M2 macrophage polarization by IL6 and MDSC conversion by GM-CSF in gallbladder carcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Hepatology"
DOI: 10.1097/hep.0000000000000028
Abstract: BACKGROUND AND AIMS Nicotinamide N-methyltransferase (NNMT), an enzyme responsible for the methylation of nicotinamide, is involved in many metabolic pathways in adipose tissue and the liver. However, the role of NNMT in editing the tumor… read more here.
Keywords: csf; expression; nicotinamide methyltransferase; gallbladder carcinoma ... See more keywords
N6-Methyladenosine RNA Modifications Regulate the Response to Platinum through Nicotinamide N-methyltransferase.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-22-0278
Abstract: Development of resistance to platinum (Pt) in ovarian cancer (OC) remains a major clinical challenge. Here we focused on identifying epitranscriptomic modifications linked to Pt resistance. FTO is a N6-methyladenosine (m6A) RNA demethylase recently described… read more here.
Keywords: rna modifications; fto; nicotinamide methyltransferase; platinum ... See more keywords
Systematic pan-cancer analysis of the nicotinamide n-methyltransferase in human cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.1000515
Abstract: In several tumors, Nicotinamide N-Methyltransferase (NNMT) was identified as a bridge between methylation metabolism and tumorigenesis and was associated with a poor prognosis. This research aims is to study the prognostic value of NNMT in… read more here.
Keywords: expression; analysis; nicotinamide methyltransferase; nnmt expression ... See more keywords
Esterase-Sensitive Prodrugs of a Potent Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT) Display Cellular Activity
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11091357
Abstract: A recently discovered bisubstrate inhibitor of Nicotinamide N-methyltransferase (NNMT) was found to be highly potent in biochemical assays with a single digit nanomolar IC50 value but lacking in cellular activity. We, here, report a prodrug… read more here.
Keywords: cellular activity; bisubstrate inhibitor; nicotinamide methyltransferase; inhibitor nicotinamide ... See more keywords