Nicotinamide Mononucleotide Ameliorates Sleep Deprivation‐Induced Gut Microbiota Dysbiosis and Restores Colonization Resistance against Intestinal Infections
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202207170
Abstract: Gut microbiota‐mediated colonization resistance (CR) is crucial in protecting the host from intestinal infections. Sleep deprivation (SD) is an important contributor in the disturbances of intestinal homeostasis. However, whether and how SD affects host CR… read more here.
Keywords: colonization resistance; nicotinamide mononucleotide; microbiota; gut microbiota ... See more keywords
Synthesis of Nicotinamide Mononucleotide from Xylose via Coupling Engineered Escherichia coli and a Biocatalytic Cascade
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200071
Abstract: β‐Nicotinamide mononucleotide (NMN) has recently gained attention for a nutritional supplement because it is an intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). In this study, we developed NMN synthesis by coupling two modules.… read more here.
Keywords: via coupling; nicotinamide mononucleotide; xylose via; mononucleotide xylose ... See more keywords
Nicotinamide mononucleotide alters body composition and ameliorates metabolic disorders induced by a high‐fat diet
Sign Up to like & getrecommendations! Published in 2023 at "IUBMB Life"
DOI: 10.1002/iub.2707
Abstract: Obesity is caused by an imbalance between calorie intake and energy expenditure, leading to excessive adipose tissue accumulation. Nicotinamide adenine dinucleotide (NAD+) is an important molecule in energy and signal transduction, and NAD+ supplementation therapy… read more here.
Keywords: nicotinamide mononucleotide; body composition; high fat; obesity ... See more keywords
Enhancing the biosynthesis of nicotinamide mononucleotide in Lactococcus lactis by heterologous expression of FtnadE.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12253
Abstract: BACKGROUND Nicotinamide mononucleotide (NMN), a key intermediate of nicotinamide adenine dinucleotide, plays an important in anti-aging and disease. Lactococcus lactis, an important probiotic lactic acid bacteria (LAB), has shown great potential for the biosynthesis of… read more here.
Keywords: nicotinamide mononucleotide; biosynthesis; heterologous expression; lactis ... See more keywords
Biological synthesis of nicotinamide mononucleotide.
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology letters"
DOI: 10.1007/s10529-021-03191-1
Abstract: Nicotinamide mononucleotide (NMN) or Nicotinamide-1-ium-1-β-D-ribofuranoside 5'-phosphate is a nucleotide that can be converted into nicotinamide adenine dinucleotide (NAD) in human cells. NMN has recently attracted great attention because of its potential as an anti-aging drug,… read more here.
Keywords: nicotinamide mononucleotide; synthesis; biological synthesis; synthesis nicotinamide ... See more keywords
Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107987
Abstract: Advanced maternal age is highly associated with a decline in oocyte quality, but effective approaches to improve it have still not been fully determined. Here, we report that in vivo supplementation of nicotinamide mononucleotide (NMN) efficaciously… read more here.
Keywords: supplementation; quality; nicotinamide mononucleotide; mononucleotide supplementation ... See more keywords
Simultaneous quantitation of nicotinamide riboside, nicotinamide mononucleotide and nicotinamide adenine dinucleotide in milk by a novel enzyme-coupled assay.
Sign Up to like & getrecommendations! Published in 2017 at "Food chemistry"
DOI: 10.1016/j.foodchem.2016.10.032
Abstract: Nicotinamide riboside, the most recently discovered form of vitamin B3, and its phosphorylated form nicotinamide mononucleotide, have been shown to be potent supplements boosting intracellular nicotinamide adenine dinucleotide (NAD) levels, thus preventing or ameliorating metabolic… read more here.
Keywords: milk; adenine dinucleotide; nicotinamide mononucleotide; nicotinamide adenine ... See more keywords
Direct Stimulation of Glycolysis Accounts for Cellular Metabolic Benefits of the NAD+ Precursor Nicotinamide Mononucleotide (NMN)
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.10.247
Abstract: In addition to metabolic and redox functions, nicotinamide adenine dinucleotide (NAD+) impacts cell signaling via the sirtuin family of lysine deacylases. Several diseases are reported to benefit from pharmacologic stimulation of sirtuin activity by delivery… read more here.
Keywords: nicotinamide mononucleotide; glycolysis; stimulation; stimulation glycolysis ... See more keywords
Kinetic and oligomeric study of Leishmania braziliensis nicotinate/nicotinamide mononucleotide adenylyltransferase
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e03733
Abstract: Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme involved in REDOX reactions and oxidative stress defense systems. Furthermore, NAD is used as substrate by proteins that regulate essential cellular functions as DNA repair, genetic, and… read more here.
Keywords: leishmania braziliensis; nicotinamide mononucleotide; braziliensis; lbnmnat protein ... See more keywords
Nicotinamide Mononucleotide and Melatonin Alleviate Aging-induced Cognitive Impairment via Modulation of Mitochondrial Function and Apoptosis in the Prefrontal Cortex and Hippocampus
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2019.09.037
Abstract: Given the fact that both melatonin and nicotinamide mononucleotide (NMN) act as pleiotropic agents in various age-related cognitive disorders, we aimed to investigate the effect of these compounds separately and together on the cognitive outcomes,… read more here.
Keywords: nicotinamide mononucleotide; mitochondrial function; function apoptosis; melatonin ... See more keywords
Yeast Cell Surface Engineering of a Nicotinamide Riboside Kinase for the Production of β-Nicotinamide Mononucleotide via Whole-Cell Catalysis.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00350
Abstract: β-Nicotinamide mononucleotide (NMN) has been widely used as a nutraceutical for self-medication. The one-step conversion of nicotinamide riboside (NR) to β-NMN has been considered to be the most promising synthetic route for β-NMN. Here, human… read more here.
Keywords: cell; nicotinamide mononucleotide; whole cell; production ... See more keywords