Nicotinamide phosphoribosyltransferase purification using SUMO expression system.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2020.113597
Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) is a rate-limiting enzyme in the salvage pathway required for nicotinamide adenine dinucleotide synthesis. The secreted NAMPT protein serves as a master regulatory cytokine involved in activation of evolutionarily-conserved inflammatory networks. Appreciation… read more here.
Keywords: protein; sumo expression; expression; purification ... See more keywords
Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity.
Sign Up to like & getrecommendations! Published in 2022 at "Cell research"
DOI: 10.1038/s41422-022-00651-9
Abstract: The decline of nicotinamide adenine dinucleotide (NAD) occurs in a variety of human pathologies including neurodegeneration. NAD-boosting agents can provide neuroprotective benefits. Here, we report the discovery and development of a class of potent activators… read more here.
Keywords: discovery small; small molecule; phosphoribosyltransferase nampt; activity ... See more keywords
MicroRNA410 Inhibits Pulmonary Vascular Remodeling via Regulation of Nicotinamide Phosphoribosyltransferase
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46352-z
Abstract: Nicotinamide phosphoribosyltransferase (NAMPT) upregulation in human pulmonary artery endothelial cells (hPAECs) is associated with pulmonary arterial hypertension (PAH) progression and pulmonary vascular remodeling. The underlying mechanisms regulating NAMPT expression are still not clear. In this… read more here.
Keywords: pulmonary vascular; mir410; vascular remodeling; nampt expression ... See more keywords
Circular RNA triple functional domain promotes osteoarthritis’ development by modulating the microRNA-136-5p/Nicotinamide phosphoribosyltransferase axis
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2021.2018095
Abstract: ABSTRACT Numerous studies have affirmed the participation of circular RNA (circRNA) in osteoarthritis (OA)’ development. Previous studies have exposed the elevation of the circRNA triple functional domain (TRIO) in OA, while the molecular mechanism of… read more here.
Keywords: triple functional; circular rna; functional domain; osteoarthritis development ... See more keywords
MiR-613 Promotes Cell Death in Breast Cancer Cells by Downregulation of Nicotinamide Phosphoribosyltransferase and Reduction of NAD.
Sign Up to like & getrecommendations! Published in 2021 at "DNA and cell biology"
DOI: 10.1089/dna.2021.0330
Abstract: NAD is mainly biosynthesized by the enzymatic action of nicotinamide phosphoribosyltransferase (NAMPT) through the salvage pathway. NAD is indispensable for the proper function and metabolism of all living cells, including cancer cells. Our previous researches… read more here.
Keywords: breast cancer; mir 613; cancer cells; cancer ... See more keywords
Nicotinamide Phosphoribosyltransferase Acts as a Metabolic Gate for Mobilization of Myeloid-Derived Suppressor Cells.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-1544
Abstract: Cancer induces alteration of hematopoiesis to fuel disease progression. We report that in tumor-bearing mice the macrophage colony-stimulating factor elevates the myeloid cell levels of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the NAD salvage… read more here.
Keywords: nicotinamide phosphoribosyltransferase; metabolic gate; mobilization; myeloid derived ... See more keywords
Abstract 1942: The nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, OT-82, exhibitsin vitroandin vivoefficacy against patient-derived xenograft models of high-risk acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1942
Abstract: Cancer cells are highly dependent on nicotinamide phosphoribosyltransferase (NAMPT) for the biosynthesis of nicotinamide adenine dinucleotide (NAD). Besides its role in energy metabolism, NAMPT influences the activity of NAD-dependent enzymes, including poly (ADP-ribose) polymerase-1 (PARP-1)… read more here.
Keywords: cell; phosphoribosyltransferase nampt; nampt inhibitor; acute lymphoblastic ... See more keywords
Abstract 5477: Targeting nicotinamide phosphoribosyltransferase (NAMPT) with OT-82 in Ewing sarcoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-5477
Abstract: EWS is an aggressive malignancy affecting adolescents and young adults, for which novel therapies are critically needed. Recent insights have revealed that NAMPT is a potential therapeutic target, mediating the rate limiting step of the… read more here.
Keywords: phosphoribosyltransferase nampt; cell lines; targeting nicotinamide; biology ... See more keywords
Extracellular Nicotinamide Phosphoribosyltransferase Is a Component of the Senescence-Associated Secretory Phenotype
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.935106
Abstract: Cellular senescence is a stress or damage response by which a cell adopts of state of essentially permanent proliferative arrest, coupled to the secretion of a number of biologically active molecules. This senescence-associated secretory phenotype… read more here.
Keywords: secretory phenotype; associated secretory; nicotinamide phosphoribosyltransferase; senescence ... See more keywords
Anticancer Activities of Novel Nicotinamide Phosphoribosyltransferase Inhibitors in Hematological Malignancies
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041897
Abstract: Targeting cancer cells that are highly dependent on the nicotinamide adenine dinucleotide (NAD+) metabolite is a promising therapeutic strategy. Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme catalyzing NAD+ production. Despite the high efficacy of several… read more here.
Keywords: anticancer activities; nicotinamide phosphoribosyltransferase; hematological malignancies; nampt inhibitors ... See more keywords
Iminosugar-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors as Potential Anti-Pancreatic Cancer Agents
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15051472
Abstract: The nicotinamide phosphoribosyltransferase (NAMPT) is considered a very promising therapeutic target because it is overexpressed in pancreatic cancer. Although many inhibitors have been prepared and tested, clinical trials have shown that NAMPT inhibition may result… read more here.
Keywords: pancreatic cancer; nicotinamide phosphoribosyltransferase; phosphoribosyltransferase nampt; iminosugar based ... See more keywords