Underpowered or negative? A crucial distinction
Sign Up to like & getrecommendations! Published in 2019 at "Diabetologia"
DOI: 10.1007/s00125-019-4853-x
Abstract: To the Editor: Schrauwen and colleagues have recently reviewed the emerging field of NAD metabolism in Diabetologia [1]. Their manuscript includes a description of a clinical trial of dietary nicotinamide riboside supplementation effects on whole… read more here.
Keywords: trial; value; study; nicotinamide riboside ... See more keywords
Nicotinamide Riboside will Play an Important Role in Anti-aging Therapy in Humans, Especially in the Face Skin Anti-aging Treatment
Sign Up to like & getrecommendations! Published in 2021 at "Aesthetic Plastic Surgery"
DOI: 10.1007/s00266-021-02335-y
Abstract: Dear Editor, Aging is a part of human life. Prolonging life span and reducing disease have always been the focus of human attention. With the aging of the population in the economically developed countries, prolonging… read more here.
Keywords: facial skin; aging treatment; aging therapy; nicotinamide riboside ... See more keywords
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.07.043
Abstract: Summary Nicotinamide adenine dinucleotide (NAD+) is modulated by conditions of metabolic stress and has been reported to decline with aging in preclinical models, but human data are sparse. Nicotinamide riboside (NR) supplementation ameliorates metabolic dysfunction… read more here.
Keywords: skeletal muscle; aged human; muscle; nicotinamide riboside ... See more keywords
Simultaneous quantitation of nicotinamide riboside, nicotinamide mononucleotide and nicotinamide adenine dinucleotide in milk by a novel enzyme-coupled assay.
Sign Up to like & getrecommendations! Published in 2017 at "Food chemistry"
DOI: 10.1016/j.foodchem.2016.10.032
Abstract: Nicotinamide riboside, the most recently discovered form of vitamin B3, and its phosphorylated form nicotinamide mononucleotide, have been shown to be potent supplements boosting intracellular nicotinamide adenine dinucleotide (NAD) levels, thus preventing or ameliorating metabolic… read more here.
Keywords: milk; adenine dinucleotide; nicotinamide mononucleotide; nicotinamide adenine ... See more keywords
Nicotinamide riboside induces a thermogenic response in lean mice
Sign Up to like & getrecommendations! Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.09.015
Abstract: Aims: Nicotinamide Riboside (NR) is a NAD+ booster with wide physiological repercussion including the improvement on glucose and lipid homeostasis, increasing the life expectancy in mammals. However, the effects of NR on metabolism are only… read more here.
Keywords: bat; thermogenic response; nicotinamide riboside; mice ... See more keywords
Yeast Cell Surface Engineering of a Nicotinamide Riboside Kinase for the Production of β-Nicotinamide Mononucleotide via Whole-Cell Catalysis.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00350
Abstract: β-Nicotinamide mononucleotide (NMN) has been widely used as a nutraceutical for self-medication. The one-step conversion of nicotinamide riboside (NR) to β-NMN has been considered to be the most promising synthetic route for β-NMN. Here, human… read more here.
Keywords: cell; nicotinamide mononucleotide; whole cell; production ... See more keywords
Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring (P11-003-19).
Sign Up to like & getrecommendations! Published in 2019 at "Current developments in nutrition"
DOI: 10.1093/cdn/nzz048.p11-003-19
Abstract: Objectives We tested the hypothesis that postpartum constitutes a metabolic stress to the nicotinamide adenine dinucleotide (NAD) system and that supplementation of mothers during postpartum with nicotinamide riboside (NR) might improve health outcomes to mothers… read more here.
Keywords: supplemented mothers; nicotinamide riboside; adult offspring; weight loss ... See more keywords
Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13754
Abstract: Declining nicotinamide adenine dinucleotide (NAD+) concentration in the brain during aging contributes to metabolic and cellular dysfunction and is implicated in the pathogenesis of aging‐associated neurological disorders. Experimental therapies aimed at boosting brain NAD+ levels… read more here.
Keywords: plasma extracellular; extracellular vesicles; pathology; vesicles enriched ... See more keywords
Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide‐induced microglial and astrocytic neuroinflammation by increasing NAD+
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15367
Abstract: Neuroinflammation is initiated by activation of the brain's innate immune system in response to an inflammatory challenge. Insufficient control of neuroinflammation leads to enhanced or prolonged pathology in various neurological conditions including multiple sclerosis and… read more here.
Keywords: supplementation; neuroinflammation; inhibition; cd38 ... See more keywords
Nicotinamide Riboside-Conditioned Microbiota Deflects High-Fat Diet-Induced Weight Gain in Mice
Sign Up to like & getrecommendations! Published in 2022 at "mSystems"
DOI: 10.1128/msystems.00230-21
Abstract: With obesity and type 2 diabetes (T2D) at epidemic levels, we need to understand the complex nature of these diseases to design better therapeutics. The underlying causes of both obesity and T2D are complex, but… read more here.
Keywords: weight gain; nicotinamide riboside; obesity; mice ... See more keywords
Metabolic Disease, NAD Metabolism, Nicotinamide Riboside, and the Gut Microbiome: Connecting the Dots from the Gut to Physiology
Sign Up to like & getrecommendations! Published in 2022 at "mSystems"
DOI: 10.1128/msystems.01223-21
Abstract: The effort to use nutrients as interventions to treat human disease has been important to medicine. A current example in this vein pertains to NAD+ boosters, such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN),… read more here.
Keywords: disease; nad metabolism; physiology; gut microbiome ... See more keywords