Nicotinamide supplementation phenocopies SIR2 inactivation by modulating carbon metabolism and respiration during yeast chronological aging
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2016.06.006
Abstract: Nicotinamide (NAM), a form of vitamin B3, is a byproduct and noncompetitive inhibitor of the deacetylation reaction catalyzed by Sirtuins. These represent a family of evolutionarily conserved NAD+-dependent deacetylases that are well-known critical regulators of… read more here.
Keywords: metabolism; nicotinamide supplementation; yeast chronological; respiration ... See more keywords
Nicotinamide protects hepatocytes against palmitate-induced lipotoxicity via SIRT1-dependent autophagy induction.
Sign Up to like & getrecommendations! Published in 2017 at "Nutrition research"
DOI: 10.1016/j.nutres.2017.03.005
Abstract: Lipotoxicity induced by saturated fatty acids (SFAs) plays a pathological role in the development of non-alcoholic fatty liver disease (NAFLD); however, the exact mechanism remains to be clearly elucidated. Palmitate is the most abundant SFA… read more here.
Keywords: nicotinamide supplementation; autophagy induction; anti lipotoxic; palmitate induced ... See more keywords