Effect of Selective Inhibition of Reactivated Nicotine-Associated Memories With Propranolol on Nicotine Craving
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2016.3907
Abstract: Importance A relapse into nicotine addiction during abstinence often occurs after the reactivation of nicotine reward memories, either by acute exposure to nicotine (a smoking episode) or by smoking-associated conditioned stimuli (CS). Preclinical studies suggest… read more here.
Keywords: nicotine; retrieval; nicotine craving; cpp operant ... See more keywords
Interconversion of nicotine enantiomers during heating and implications for smoke from combustible cigarettes, heated tobacco products, and electronic cigarettes.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23421
Abstract: Physiological properties of (R)-nicotine have differences compared with (S)-nicotine, and the subject of (S)- and (R)-nicotine ratio in smoking or vaping related items is of considerable interest. A Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS) method for… read more here.
Keywords: nicotine; tobacco products; smoke combustible; heated tobacco ... See more keywords
c‐Fos marking of identified midbrain neurons coactive after nicotine administration in‐vivo
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24471
Abstract: Despite the reduced life expectancy and staggering financial burden of medical treatment associated with tobacco smoking, the molecular, cellular, and ensemble adaptations associated with chronic nicotine consumption remain poorly understood. Complex circuitry interconnecting dopaminergic and… read more here.
Keywords: nicotine; chronic nicotine; activation; marking identified ... See more keywords
Pharmacokinetics of freebase nicotine and nicotine salts following subcutaneous administration in male rats.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3363
Abstract: Nicotine lactate, nicotine tartrate, nicotine benzoate, and freebase nicotine (FBN) are four forms of nicotine salt systems that are present in tobacco products. However, few in vivo studies have compared their pharmacological (pK) efficacies, which… read more here.
Keywords: nicotine salts; nicotine nicotine; nicotine; freebase nicotine ... See more keywords
Allosteric modulation of α4β2* nicotinic acetylcholine receptors: Desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pain"
DOI: 10.1002/ejp.1092
Abstract: Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand‐gated ion channels. The α4β2 subtype of nAChRs plays an important role in the mediation of pain and several nicotine‐evoked responses. Agonists and partial agonists of α4β2 nAChRs show… read more here.
Keywords: nicotine; acetylcholine receptors; nicotinic acetylcholine; allosteric modulation ... See more keywords
Nicotine increases colon cancer cell migration and invasion through epithelial to mesenchymal transition (EMT): COX‐2 involvement
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26323
Abstract: Cigarette smoking is a recognized risk factor for colon cancer and nicotine, the principal active component of tobacco, plays a pivotal role in increasing colon cancer cell growth and survival. The aim of this study… read more here.
Keywords: nicotine; colon; migration; colon cancer ... See more keywords
Nicotine increases anterior insula activation to expected and unexpected outcomes among nonsmokers
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4550-8
Abstract: RationaleTobacco has a higher rate of dependence than other drugs of abuse. However, the psychopharmacological effects of nicotine are incongruent with the tenacity of tobacco addiction since nicotine does not produce robust euphoria in humans… read more here.
Keywords: nicotine; nicotine increases; activation; increases anterior ... See more keywords
Habitual nicotine-seeking in rats following limited training
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4655-0
Abstract: Rationale and objectivesA potential reason that cigarette smoking can persist despite multiple quit attempts is that repeated voluntary nicotine intake may facilitate a transition from goal-directed to habitual behavioral control. Although accelerated habit formation for… read more here.
Keywords: nicotine; nicotine seeking; control; responding nicotine ... See more keywords
Nicotine e-cigarette vapor inhalation effects on nicotine & cotinine plasma levels and somatic withdrawal signs in adult male Wistar rats
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05400-2
Abstract: Rationale Non-contingent chronic nicotine exposure procedures have evolved rapidly in recent years, culminating in electronic nicotine delivery systems (ENDS or e-cigarettes) to deliver vaporized drugs to rodents in standard housing chambers. Objectives The aim of… read more here.
Keywords: nicotine; withdrawal signs; vapor; somatic withdrawal ... See more keywords
Anticataleptic activity of nicotine in rats: involvement of the lateral entorhinal cortex.
Sign Up to like & getrecommendations! Published in 2021 at "Psychopharmacology"
DOI: 10.1007/s00213-021-05870-3
Abstract: RATIONALE Recently, it was found that cyclosomatostatin-induced catalepsy in middle-aged rats is accompanied by neuronal hypoactivation in the lateral entorhinal cortex (LEntCx); this hypoactivation was reversed by systemic administration of nicotine combined with diphenhydramine. These… read more here.
Keywords: nicotine; entorhinal cortex; cortex; activity nicotine ... See more keywords
Site-specific peak intensity ratio (SPIR) from 1D 2H/1H NMR spectra for rapid distinction between natural and synthetic nicotine and detection of possible adulteration
Sign Up to like & getrecommendations! Published in 2019 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-019-02023-6
Abstract: Abstract1H and 2H NMR spectra of 4 natural and synthetic nicotine samples were collected in a non-quantitative way and site-specific 2H/1H peak intensity ratio (SPIR) was calculated for 12 distinct sites of nicotine. Experimental results… read more here.
Keywords: nicotine; synthetic nicotine; site specific; ratio ... See more keywords