Nicotine-derived NNK induces the stemness enrichment of CRC cells through regulating the balance of DUSP4-ERK1/2 feedback loop.
Sign Up to like & getrecommendations! Published in 2021 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2021.112057
Abstract: Cigarette smoking has been considered as an independent risk factor for colorectal cancer (CRC) initiation and progression. In this study, we found that cigarette smoking was significantly associated with poor CRC differentiation (P = 0.040). Since studies… read more here.
Keywords: crc cells; nicotine derived; stemness enrichment; crc ... See more keywords
Effects of Tobacco Nicotine-Derived Nitrosamine Ketone (NNK) Exposures on Brain Alcohol Metabolizing Enzyme Activities.
Sign Up to like & getrecommendations! Published in 2018 at "Drug metabolism letters"
DOI: 10.2174/1872312812666180611115418
Abstract: BACKGROUND The high levels of blood alcohol achieved with chronic plus binge alcohol exposures are somewhat reduced by co-administration of tobacco-specific Nicotine-Derived Nitrosamine Ketone (NNK) suggesting that NNK may alter alcohol metabolism. OBJECTIVE We examined… read more here.
Keywords: nitrosamine ketone; nicotine derived; nnk; derived nitrosamine ... See more keywords