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Social context has differential effects on acquisition of nicotine self-administration in male and female rats

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0 Published in 2017 at "Psychopharmacology"

DOI: 10.1007/s00213-017-4590-0

Abstract: RationalSmoking typically begins during adolescence or early adulthood in a social context, yet the role of social context in animal models is poorly understood.ObjectivesThe present study examined the effect of social context on acquisition of… read more here.

Keywords: self administration; context; acquisition nicotine; nicotine self ... See more keywords

Differential efficacies of the nicotinic α4β2 desensitizing agents in reducing nicotine self-administration in female rats

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1 Published in 2017 at "Psychopharmacology"

DOI: 10.1007/s00213-017-4641-6

Abstract: Rationale and objectivesDesensitization of neuronal nicotinic acetylcholine receptors holds promise as an effective treatment of tobacco addiction. Previously, we found that sazetidine-A (Saz-A), which selectively desensitizes α4β2 nicotinic receptors, significantly decreased intravenous (IV) nicotine self-administration… read more here.

Keywords: self administration; administration; desensitizing agents; efficacies nicotinic ... See more keywords

Adolescent nicotine and tobacco smoke exposure enhances nicotine self-administration in female rats

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1 Published in 2020 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2020.108243

Abstract: Most people start experimenting with tobacco products or e-cigarettes in early adolescence and become habitual smokers in late adolescence or adulthood. These studies investigated if exposure to tobacco smoke or nicotine during early and mid-adolescence… read more here.

Keywords: self administration; tobacco; adolescence; exposure ... See more keywords

Highly Selective and Potent α4β2 nAChR Antagonist Inhibits Nicotine Self-Administration and Reinstatement in Rats.

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1 Published in 2017 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.7b01250

Abstract: The α4β2 nAChR is the most predominant subtype in the brain and is a well-known culprit for nicotine addiction. Previously we presented a series of α4β2 nAChR selective compounds that were discovered from a mixture-based… read more here.

Keywords: self administration; selective potent; administration; highly selective ... See more keywords

Social and anxiety-like behaviors contribute to nicotine self-administration in adolescent outbred rats

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0 Published in 2018 at "Scientific Reports"

DOI: 10.1038/s41598-018-36263-w

Abstract: Both emotional and social traits interact with genetic factors to influence smoking behavior. We previously established a socially acquired nicotine intravenous self-administration model where social learning of a nicotine-associated odor cue reversed conditioned flavor aversion… read more here.

Keywords: self administration; adolescent; anxiety; nicotine self ... See more keywords