Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201800325
Abstract: A novel series of 30 symmetric bispyridinium and related N‐heteroaromatic bisquaternary salts with a propane‐1,3‐diyl linker was synthesized and characterized for their binding affinity at the MB327 binding site of nicotinic acetylcholine receptor (nAChR) from… read more here.
Keywords: series; acetylcholine receptor; nicotinic acetylcholine; mb327 ... See more keywords
Nicotinic acetylcholine receptors in a songbird brain
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.25314
Abstract: Nicotinic acetylcholine receptors (nAChRs) are ligand‐gated ion channels that mediate fast synaptic transmission and cell signaling, which contribute to learning, memory, and the execution of motor skills. Birdsong is a complex learned motor skill in… read more here.
Keywords: acetylcholine receptors; brain; nicotinic acetylcholine; nachr subunits ... See more keywords
Allosteric modulation of α4β2* nicotinic acetylcholine receptors: Desformylflustrabromine potentiates antiallodynic response of nicotine in a mouse model of neuropathic pain
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pain"
DOI: 10.1002/ejp.1092
Abstract: Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand‐gated ion channels. The α4β2 subtype of nAChRs plays an important role in the mediation of pain and several nicotine‐evoked responses. Agonists and partial agonists of α4β2 nAChRs show… read more here.
Keywords: nicotine; acetylcholine receptors; nicotinic acetylcholine; allosteric modulation ... See more keywords
Unraveling individual host–guest interactions in molecular recognition from first principles quantum mechanics: Insights into the nature of nicotinic acetylcholine receptor agonist binding
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Computational Chemistry"
DOI: 10.1002/jcc.26454
Abstract: Drug binding to a protein target is governed by a complex pattern of noncovalent interactions between the ligand and the residues in the protein's binding pocket. Here we introduce a generally applicable, parameter‐free, computational method… read more here.
Keywords: guest interactions; nicotinic acetylcholine; host guest; molecular recognition ... See more keywords
SELECTIVE ACTIONS OF INSECTICIDES ON DESENSITIZING and NON-DESENSITIZING NICOTINIC ACETYLCHOLINE RECEPTORS IN COCKROACH (Periplaneta americana) NEURONS.
Sign Up to like & getrecommendations! Published in 2021 at "Pest management science"
DOI: 10.1002/ps.6396
Abstract: BACKGROUND Insect desensitizing nicotinic acetylcholine (nAChD) receptors are desensitized by low concentrations of agonists, including neonicotinoid insecticides, but are essentially insensitive to spinosyns, while non-desensitizing nicotinic acetylcholine (nAChN) receptors are selectively activated by spinosyns and… read more here.
Keywords: acetylcholine; desensitizing nicotinic; nicotinic acetylcholine; non desensitizing ... See more keywords
Evaluation of the Relationship Between Cognitive Impairment, Glycometabolism, and Nicotinic Acetylcholine Receptor Deficits in a Mouse Model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-018-1253-4
Abstract: PurposeIn patients with Alzheimer’s disease (AD), the loss of cerebral nicotinic acetylcholine receptors (nAChRs) that are implicated in higher brain functions has been reported. However, it is unclear if nAChR deficits occur in association with… read more here.
Keywords: cognitive impairments; age; alzheimer disease; nicotinic acetylcholine ... See more keywords
Not Goanna Get Me: Mutations in the Savannah Monitor Lizard (Varanus exanthematicus) Nicotinic Acetylcholine Receptor Confer Reduced Susceptibility to Sympatric Cobra Venoms.
Sign Up to like & getrecommendations! Published in 2021 at "Neurotoxicity research"
DOI: 10.1007/s12640-021-00351-z
Abstract: Antagonistic coevolutionary relationships provide intense selection pressure which drive changes in the genotype. Predator-prey interactions have caused some venomous snakes and their predators/prey to evolve α-neurotoxin resistance through changes at the orthosteric site of nicotinic… read more here.
Keywords: negatively charged; charged amino; susceptibility; nicotinic acetylcholine ... See more keywords
Nicotine Suppresses the Invasiveness of Human Trophoblasts by Downregulation of CXCL12 Expression through the Alpha-7 Subunit of the Nicotinic Acetylcholine Receptor
Sign Up to like & getrecommendations! Published in 2020 at "Reproductive Sciences"
DOI: 10.1007/s43032-019-00095-4
Abstract: Smoke exposure during pregnancy has detrimental effects upon numerous fetal and neonatal outcomes. Nicotine (the main component of tobacco) has been suggested to affect placental development. During placental development, efficient invasion by trophoblasts is required… read more here.
Keywords: invasion; trophoblast invasion; cxcl12 expression; nicotinic acetylcholine ... See more keywords
Nicotinic α7 acetylcholine receptor (α7nAChR) in human airway smooth muscle.
Sign Up to like & getrecommendations! Published in 2021 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2021.108897
Abstract: Diseases such as asthma are exacerbated by inflammation, cigarette smoke and even nicotine delivery devices such as e-cigarettes. However, there is currently little information on how nicotine affects airways, particularly in humans, and changes in… read more here.
Keywords: nicotinic acetylcholine; 7nachr human; smooth muscle; acetylcholine receptor ... See more keywords
Nicotinic acetylcholine receptor alpha 7 stimulation dampens splenic myelopoiesis and inhibits atherogenesis in Apoe-/- mice.
Sign Up to like & getrecommendations! Published in 2017 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2017.08.010
Abstract: BACKGROUND AND AIMS Monocyte levels predict cardiovascular outcomes and play a causal role in atherogenesis. Monocytes can be produced in the spleen and track to the atherosclerotic lesion in significant numbers. The cholinergic system has… read more here.
Keywords: splenic myelopoiesis; stimulation; receptor alpha; nicotinic acetylcholine ... See more keywords
Activation of α7 nicotinic acetylcholine receptors attenuates monocyte-endothelial adhesion through FUT7 inhibition.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2021.12.094
Abstract: Cholinergic anti-inflammatory pathway (CAP) describes a neuronal-inflammatory reflex centered on systemic cytokine regulation by α7 nicotinic acetylcholine receptor (α7nAChR) activation of spleen-residue macrophage. However, the CAP mechanism attenuating distal tissue inflammation, inducing a low level… read more here.
Keywords: fut7 inhibition; nicotinic acetylcholine; activation; adhesion ... See more keywords