Molecular function of the novel α7β2 nicotinic receptor
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2741-4
Abstract: The α7 nicotinic receptor is a promising drug target for neurological and inflammatory disorders. Although it is the homomeric member of the family, a novel α7β2 heteromeric receptor has been discovered. To decipher the functional… read more here.
Keywords: receptor; nicotinic receptor; function novel; activation ... See more keywords
Co-modulation of an allosteric modulator of nicotinic receptor-cholinesterase inhibitor (galantamine) and a 5-HT4 receptor agonist (RS-67333): effect on scopolamine-induced memory deficit in the mouse
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4664-z
Abstract: AimIt is widely assumed that the upcoming therapeutics for Alzheimer’s disease will require to act on more than one target to be effective. We investigated here whether a combination of the nicotinic receptor allosteric modulator/cholinesterase… read more here.
Keywords: allosteric modulator; nicotinic receptor; galantamine; effect ... See more keywords
Nicotine prevents alpha-synuclein accumulation in mouse and human iPSC-derived dopaminergic neurons through activation of the dopamine D3- acetylcholine nicotinic receptor heteromer
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2019.04.017
Abstract: We recently found that in mouse dopaminergic neurons, the heteromer formed by the dopamine D3 receptor (D3R) and the β2 subunit of acetylcholine nicotinic receptor (nAChR) exerts neurotrophic effects when activated by nicotine, leading to… read more here.
Keywords: nicotinic receptor; alpha synuclein; dopaminergic neurons; acetylcholine nicotinic ... See more keywords
Golden Anniversary of the Nicotinic Receptor
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2020.05.026
Abstract: The high-resolution structure of the nicotinic acetylcholine receptor from Torpedo electric tissue in association with the snake toxin α-bungarotoxin (Rahman et al., 2020) is presented 50 years after its identification as the first neurotransmitter receptor and… read more here.
Keywords: receptor; golden anniversary; anniversary nicotinic; nicotinic receptor ... See more keywords
Enantiospecific Positive Allosteric Modulation of α4β2 Nicotinic Receptor Subtypes.
Sign Up to like & getrecommendations! Published in 2025 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.5c00115
Abstract: Nicotinic acetylcholine receptors (nAChRs) are integral to brain function, playing critical roles in cognition and reward pathways. Among these, α4β2 nAChRs are key targets for developing therapeutics to address nicotine addiction and cognitive disorders. Here,… read more here.
Keywords: modulation nicotinic; nicotinic receptor; gat2802; positive allosteric ... See more keywords
Selective α7 nicotinic receptor agonists and positive allosteric modulators for the treatment of schizophrenia – a review
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2020.1764938
Abstract: ABSTRACT Introduction Alpha 7 nicotinic acetylcholine receptor (α7 nAChR) partial agonists, agonists, and positive allosteric modulators (PAMs) have been in development for over a decade. The initial candidates were in clinical trials for a wide… read more here.
Keywords: agonists positive; schizophrenia; nicotinic receptor; allosteric modulators ... See more keywords
Pharmacological characterization of 5-iodo-A-85380, a β2-selective nicotinic receptor agonist, in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Psychopharmacology"
DOI: 10.1177/02698811221132214
Abstract: Background: Because of their implications in several pathological conditions, α4β2* nicotinic acetylcholine receptors (nAChRs) are potential targets for the treatment of nicotine dependence, pain, and many psychiatric and neurodegenerative diseases. However, they exist in various… read more here.
Keywords: agonist; iodo 85380; nicotinic receptor; containing subtypes ... See more keywords
Uncovering the transcriptomic and epigenomic landscape of nicotinic receptor genes in non-neuronal tissues
Sign Up to like & getrecommendations! Published in 2017 at "BMC Genomics"
DOI: 10.1186/s12864-017-3813-4
Abstract: BackgroundNicotinic acetylcholine receptors (nAChRs) play an important role in cellular physiology and human nicotine dependence, and are closely associated with many human diseases including cancer. For example, previous studies suggest that nAChRs can re-wire gene… read more here.
Keywords: epigenomic landscape; nicotinic receptor; chrna4; non neuronal ... See more keywords
Insights into Crystallization of Neuronal Nicotinic α4β2 Receptor in Polarized Lipid Matrices
Sign Up to like & getrecommendations! Published in 2024 at "Crystals"
DOI: 10.3390/cryst14100889
Abstract: Obtaining high-resolution 3D structures of membrane proteins through X-ray crystallography remains a longstanding bottleneck in the field of structural biology. This challenge has led to the optimization of purification methods to acquire high-yielding, pure proteins… read more here.
Keywords: neuronal nicotinic; polarized lipid; nicotinic receptor; insights crystallization ... See more keywords
Cholinergic Modulation of Neuroinflammation: Focus on α7 Nicotinic Receptor
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22094912
Abstract: All nervous system pathologies (e.g., neurodegenerative/demyelinating diseases and brain tumours) develop neuroinflammation, a beneficial process during pathological events, aimed at removing damaged cells, toxic agents, and/or pathogens. Unfortunately, excessive inflammation frequently occurs during nervous system… read more here.
Keywords: modulation neuroinflammation; cholinergic modulation; neuroinflammation; nicotinic receptor ... See more keywords
Structure, Dynamics, and Ligand Recognition of Human-Specific CHRFAM7A (Dupα7) Nicotinic Receptor Linked to Neuropsychiatric Disorders
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22115466
Abstract: Cholinergic α7 nicotinic receptors encoded by the CHRNA7 gene are ligand-gated ion channels directly related to memory and immunomodulation. Exons 5–7 in CHRNA7 can be duplicated and fused to exons A-E of FAR7a, resulting in… read more here.
Keywords: dup; dup subunits; nicotinic receptor; structure dynamics ... See more keywords