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Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2741-4
Abstract: The α7 nicotinic receptor is a promising drug target for neurological and inflammatory disorders. Although it is the homomeric member of the family, a novel α7β2 heteromeric receptor has been discovered. To decipher the functional…
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Keywords:
receptor;
nicotinic receptor;
function novel;
activation ... See more keywords
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Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4664-z
Abstract: AimIt is widely assumed that the upcoming therapeutics for Alzheimer’s disease will require to act on more than one target to be effective. We investigated here whether a combination of the nicotinic receptor allosteric modulator/cholinesterase…
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Keywords:
allosteric modulator;
nicotinic receptor;
galantamine;
effect ... See more keywords
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Published in 2019 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2019.04.017
Abstract: We recently found that in mouse dopaminergic neurons, the heteromer formed by the dopamine D3 receptor (D3R) and the β2 subunit of acetylcholine nicotinic receptor (nAChR) exerts neurotrophic effects when activated by nicotine, leading to…
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Keywords:
nicotinic receptor;
alpha synuclein;
dopaminergic neurons;
acetylcholine nicotinic ... See more keywords
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Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2020.05.026
Abstract: The high-resolution structure of the nicotinic acetylcholine receptor from Torpedo electric tissue in association with the snake toxin α-bungarotoxin (Rahman et al., 2020) is presented 50 years after its identification as the first neurotransmitter receptor and…
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Keywords:
receptor;
golden anniversary;
anniversary nicotinic;
nicotinic receptor ... See more keywords
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Published in 2020 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2020.1764938
Abstract: ABSTRACT Introduction Alpha 7 nicotinic acetylcholine receptor (α7 nAChR) partial agonists, agonists, and positive allosteric modulators (PAMs) have been in development for over a decade. The initial candidates were in clinical trials for a wide…
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Keywords:
agonists positive;
schizophrenia;
nicotinic receptor;
allosteric modulators ... See more keywords
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Published in 2022 at "Journal of Psychopharmacology"
DOI: 10.1177/02698811221132214
Abstract: Background: Because of their implications in several pathological conditions, α4β2* nicotinic acetylcholine receptors (nAChRs) are potential targets for the treatment of nicotine dependence, pain, and many psychiatric and neurodegenerative diseases. However, they exist in various…
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Keywords:
agonist;
iodo 85380;
nicotinic receptor;
containing subtypes ... See more keywords
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Published in 2017 at "BMC Genomics"
DOI: 10.1186/s12864-017-3813-4
Abstract: BackgroundNicotinic acetylcholine receptors (nAChRs) play an important role in cellular physiology and human nicotine dependence, and are closely associated with many human diseases including cancer. For example, previous studies suggest that nAChRs can re-wire gene…
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Keywords:
epigenomic landscape;
nicotinic receptor;
chrna4;
non neuronal ... See more keywords
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Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22094912
Abstract: All nervous system pathologies (e.g., neurodegenerative/demyelinating diseases and brain tumours) develop neuroinflammation, a beneficial process during pathological events, aimed at removing damaged cells, toxic agents, and/or pathogens. Unfortunately, excessive inflammation frequently occurs during nervous system…
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Keywords:
modulation neuroinflammation;
cholinergic modulation;
neuroinflammation;
nicotinic receptor ... See more keywords
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Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22115466
Abstract: Cholinergic α7 nicotinic receptors encoded by the CHRNA7 gene are ligand-gated ion channels directly related to memory and immunomodulation. Exons 5–7 in CHRNA7 can be duplicated and fused to exons A-E of FAR7a, resulting in…
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Keywords:
dup;
dup subunits;
nicotinic receptor;
structure dynamics ... See more keywords
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Published in 2022 at "Molecules"
DOI: 10.3390/molecules27144527
Abstract: The process of how multimeric transmembrane proteins fold and assemble in the endoplasmic reticulum is not well understood. The alpha7 nicotinic receptor (α7 nAChR) is a good model for multimeric protein assembly since it has…
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Keywords:
chaperones facilitate;
ric chaperones;
facilitate nicotinic;
nicotinic receptor ... See more keywords