Ligand Induced Changes in the Assembly of Nicotinic Receptors
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.1626
Abstract: Tobacco smoking is the leading cause of preventable death in the world. Nicotine the primary compound found in tobacco smoke has been found to alter the assembly of some subtypes of nicotinic receptors. Although the… read more here.
Keywords: induced changes; assembly nicotinic; nicotinic receptors; ligand induced ... See more keywords
Activation of α7 nicotinic receptors suppresses sucrose addiction in mice
Sign Up to like & getrecommendations! Published in 2022 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2021.110439
Abstract: The mesolimbic dopamine system is important for the rewarding and motivational aspects of consuming rewarding and palatable food. Nicotinic receptors are present in the mesolimbic dopamine system and enhance the reinforcement of drugs of abuse.… read more here.
Keywords: sucrose preference; nicotinic receptors; sucrose addiction; suppresses sucrose ... See more keywords
New Rigid Nicotine Analogues, Carrying a Norbornane Moiety, Are Potent Agonists of α7 and α3* Nicotinic Receptors.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b01372
Abstract: A three-dimensional database search has been applied to design a series of endo- and exo-3-(pyridin-3-yl)bicyclo[2.2.1]heptan-2-amines as nicotinic receptor ligands. The synthesized compounds were tested in radioligand binding assay on rat cortex against [3H]-cytisine and [3H]-methyllycaconitine… read more here.
Keywords: rigid nicotine; new rigid; nicotinic receptors; receptors new ... See more keywords
α7 nicotinic receptors play a role in regulation of cardiac hemodynamics.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15821
Abstract: The α7 nicotinic receptors (NR) have been confirmed in the heart but their role in cardiac functions have been contradictory. To address these contradictory finding, we analyzed cardiac functions in α7 NR knockout mice (α7-/-… read more here.
Keywords: nicotinic receptors; role; play role; receptors play ... See more keywords
α9-Containing Nicotinic Receptors in Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2021.805123
Abstract: Neuronal nicotinic acetylcholine receptors containing the α9 or the α9 and α10 subunits are expressed in various extra-neuronal tissues. Moreover, most cancer cells and tissues highly express α9-containing receptors, and a number of studies have… read more here.
Keywords: cancer; receptors cancer; nicotinic receptors; containing nicotinic ... See more keywords
The Anti-Aggregative Peptide KLVFF Mimics Aβ1-40 in the Modulation of Nicotinic Receptors: Implications for Peptide-Based Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10092231
Abstract: In recent years, the inhibition of beta-amyloid (Aβ) aggregation has emerged as a potential strategy for Alzheimer’s disease. KLVFF, a small peptide corresponding to the aminoacidic sequence 16-20 of Aβ, reduces Aβ fibrillation dose dependently.… read more here.
Keywords: nicotinic receptors; klvff; peptide; klvff mimics ... See more keywords
α3β4 Acetylcholine Nicotinic Receptors Are Components of the Secretory Machinery Clusters in Chromaffin Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23169101
Abstract: The heteromeric assembly of α3 and β4 subunits of acetylcholine nicotinic receptors (nAChRs) seems to mediate the secretory response in bovine chromaffin cells. However, there is no information about the localization of these nAChRs in… read more here.
Keywords: nicotinic receptors; receptors components; microscopy; machinery ... See more keywords