Noradrenaline is crucial for the substantia nigra dopaminergic cell maintenance
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2019.104551
Abstract: In Parkinson's disease, degeneration of substantia nigra dopaminergic neurons is accompanied by damage on other neuronal systems. A severe denervation is for example seen in the locus coerulean noradrenergic system. Little is known about the… read more here.
Keywords: nigra dopaminergic; substantia nigra; dsp4; denervation ... See more keywords
Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abp8701
Abstract: How do neurons match generation of adenosine triphosphate by mitochondria to the bioenergetic demands of regenerative activity? Although the subject of speculation, this coupling is still poorly understood, particularly in neurons that are tonically active.… read more here.
Keywords: couple spiking; nigra dopaminergic; channels couple; substantia nigra ... See more keywords