Preventing Neurons and Glial Cells Destruction in Substantia Nigra Pars Compacta and Striatum Using St. John's Wort and Stem Cells on Parkinson's Model.
Sign Up to like & getrecommendations! Published in 2025 at "Brain and behavior"
DOI: 10.1002/brb3.71124
Abstract: St. John's wort (Hypericum perforatum) has been used for centuries as a medicinal plant to remedy external disorders such as burns and wounds, as well as internal disorders such as nerve pain, anxiety, and depression.… read more here.
Keywords: cells parkinson; stem; stem cells; john wort ... See more keywords
Susceptibility Magnetic Resonance Imaging Correlates with Glial Density and Tau in the Substantia Nigra Pars Compacta
Sign Up to like & getrecommendations! Published in 2023 at "Movement Disorders"
DOI: 10.1002/mds.29311
Abstract: Susceptibility magnetic resonance imaging (MRI) is sensitive to iron‐related changes in the substantia nigra pars compacta (SNc), the key pathologic locus of parkinsonisms. It is unclear, however, if iron deposition in the SNc is associated… read more here.
Keywords: magnetic resonance; pars compacta; nigra pars; resonance imaging ... See more keywords
Characterization of age-related microstructural changes in locus coeruleus and substantia nigra pars compacta
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2019.11.016
Abstract: Locus coeruleus (LC) and substantia nigra pars compacta (SNpc) degrade with normal aging, but not much is known regarding how these changes manifest in MRI images, or whether these markers predict aspects of cognition. Here,… read more here.
Keywords: pars compacta; nigra pars; locus coeruleus; substantia nigra ... See more keywords
Corticonigral projections recruit substantia nigra pars lateralis dopaminergic neurons for auditory threat memories
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-63132-8
Abstract: Dopaminergic neurons (DANs) in the substantia nigra pars lateralis (SNL) project to the tail of striatum, where they contribute to threat behaviors. Auditory cortex contributes to threat conditioning, but whether it directly modulates DANs is… read more here.
Keywords: auditory threat; threat; snl dans; nigra pars ... See more keywords
Inhibition of the substantia nigra pars reticulata produces divergent effects on sensorimotor gating in rats and monkeys
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27577-w
Abstract: The basal ganglia are an evolutionarily old group of structures, with gross organization conserved across species. Despite this conservation, there is evidence suggesting that anatomical organization of a key output nucleus of the basal ganglia,… read more here.
Keywords: snpr; ppi; across species; nigra pars ... See more keywords
Contribution of glutamatergic projections to neurons in the nonhuman primate substantia nigra pars reticulata for reactive inhibition
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2427032122
Abstract: Significance Understanding how the basal ganglia facilitate desired actions while suppressing unwanted ones is fundamental to neuroscience. This study shows that neurons in the primate substantia nigra pars reticulata (SNr) bidirectionally modulate activity to control… read more here.
Keywords: glutamatergic; primate substantia; pars reticulata; inhibition ... See more keywords
6‐Hydroxydopamine lesion and levodopa treatment modify the effect of buspirone in the substantia nigra pars reticulata
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15145
Abstract: l‐DOPA‐induced dyskinesia (LID) is considered a major complication in the treatment of Parkinson's disease (PD). Buspirone (5‐HT1A partial agonist) have shown promising results in the treatment of PD and LID, however no 5‐HT‐based treatment has… read more here.
Keywords: nigra pars; pars reticulata; treatment; substantia nigra ... See more keywords
Restoring failed inhibition in the substantia nigra pars reticulata suppresses absence seizures in rats.
Sign Up to like & getrecommendations! Published in 2025 at "Epilepsia"
DOI: 10.1111/epi.18701
Abstract: OBJECTIVE For over four decades, the substantia nigra pars reticulata (SNr) has been recognized as a critical structure in the modulation of seizure activity. Pharmacological and optogenetic inhibition of the SNr produces robust seizure suppression… read more here.
Keywords: pars reticulata; inhibition; seizure; nigra pars ... See more keywords
Hemisphere-specific characterization of projections from the Pedunculopontine Tegmental Nucleus to Substantia Nigra pars Compacta dopaminergic neurons
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732734
Abstract: The neurotransmitter dopamine has been shown to be implicated in motivation and reward, notably in the nigrostriatal dopaminergic pathway. Within this pathway, our research focuses on the synapse between the midbrain regions pedunculopontine tegmental nucleus… read more here.
Keywords: nigra pars; pedunculopontine tegmental; substantia nigra; tegmental nucleus ... See more keywords
Netrin 1-Mediated Role of the Substantia Nigra Pars Compacta and Ventral Tegmental Area in the Guidance of the Medial Habenular Axons
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.682067
Abstract: The fasciculus retroflexus is an important fascicle that mediates reward-related behaviors and is associated with different psychiatric diseases. It is the main habenular efference and constitutes a link between forebrain regions, the midbrain, and the… read more here.
Keywords: pars compacta; nigra pars; compacta ventral; substantia nigra ... See more keywords
Evidence That Substantia Nigra Pars Compacta Dopaminergic Neurons Are Selectively Vulnerable to Oxidative Stress Because They Are Highly Metabolically Active
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.826193
Abstract: There are 400–500 thousand dopaminergic cells within each side of the human substantia nigra pars compacta (SNpc) making them a minuscule portion of total brain mass. These tiny clusters of cells have an outsized impact… read more here.
Keywords: stress; pars compacta; nigra pars; substantia nigra ... See more keywords