Editorial for “Aberrant Hyperconnectivity of Amygdala‐Accumbens‐Pallidum Pathway Is Associated With Disorganized Nigrostriatal Pathway in Parkinson's Disease”
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.27282
Abstract: As we enter the era of precision medicine, and in the absence of reliable disease-specific biomarkers, it is fundamental to identify probes helping characterize in vivo and noninvasively the anatomical–functional organization of the human brain… read more here.
Keywords: disease; amygdala accumbens; nigrostriatal pathway; pathway ... See more keywords
Graded 6-OHDA-induced dopamine depletion in the nigrostriatal pathway evokes progressive pathological neuronal activities in the subthalamic nucleus of a hemi-parkinsonian mouse
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.02.014
Abstract: Recent studies have established methods for establishing a rodent model that mimics progressive stages of human Parkinson's disease (PD), via injection of graded doses of 6-hydroxydopamine (6-OHDA) into regions within the nigrostriatal pathway. However, the… read more here.
Keywords: hemi parkinsonian; parkinsonian mouse; nigrostriatal pathway; model ... See more keywords
Genetic elimination of dopamine vesicular stocks in the nigrostriatal pathway replicates Parkinson’s disease motor symptoms without neuronal degeneration in adult mice
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12810-9
Abstract: The type 2 vesicular monoamine transporter (VMAT2), by regulating the storage of monoamines transmitters into synaptic vesicles, has a protective role against their cytoplasmic toxicity. Increasing evidence suggests that impairment of VMAT2 neuroprotection contributes to… read more here.
Keywords: motor symptoms; vmat2; nigrostriatal pathway; motor ... See more keywords
Single-Cell Transcriptomics and In Situ Morphological Analyses Reveal Microglia Heterogeneity Across the Nigrostriatal Pathway
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.639613
Abstract: Microglia are the resident immune effector cells of the central nervous system (CNS) rapidly reacting to various pathological stimuli to maintain CNS homeostasis. However, microglial reactions in the CNS may also worsen neurological disorders. Hence,… read more here.
Keywords: single cell; heterogeneity; nigrostriatal pathway; situ morphological ... See more keywords
Axonal Tract Reconstruction Using a Tissue-Engineered Nigrostriatal Pathway in a Rat Model of Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232213985
Abstract: Parkinson’s disease (PD) affects 1–2% of people over 65, causing significant morbidity across a progressive disease course. The classic PD motor deficits are caused by the degeneration of dopaminergic neurons in the substantia nigra pars… read more here.
Keywords: engineered nigrostriatal; parkinson disease; tissue engineered; nigrostriatal pathway ... See more keywords