GDNF-mediated rescue of the nigrostriatal system depends on the degree of degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Gene Therapy"
DOI: 10.1038/s41434-018-0049-0
Abstract: Glial cell-line derived neurotrophic factor (GDNF) is a promising therapeutic molecule to treat Parkinson’s disease. Despite an excellent profile in experimental settings, clinical trials testing GDNF have failed. One of the theories to explain these… read more here.
Keywords: gdnf expression; nigrostriatal system; degeneration; nigrostriatal degeneration ... See more keywords
Effects of ERK1/2 kinases inactivation on the nigrostriatal system of Krushinsky-Molodkina rats genetically prone to audiogenic seizures
Sign Up to like & getrecommendations! Published in 2017 at "Neurological Research"
DOI: 10.1080/01616412.2017.1356156
Abstract: Abstract Recently, we demonstrated that inhibition of ERK1/2 activity by SL-327 treatment blocks seizure behavior in Krushinsky-Molodkina (KM) rats, which was mediated by altering of GABA and glutamate release mechanism in the hippocampus. Basal ganglia… read more here.
Keywords: molodkina rats; system; krushinsky molodkina; substantia nigra ... See more keywords
Time-dependent alterations in the rat nigrostriatal system after intrastriatal injection of fibrils formed by α–Syn and tau fragments
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1049418
Abstract: Introduction Accurate demonstration of phosphorylated α-synuclein aggregation and propagation, progressive nigrostriatal degeneration and motor deficits will help further research on elucidating the mechanisms of Parkinson’s Disease. α-synucleinN103 and tauN368, cleaved by activated asparagine endopeptidase in… read more here.
Keywords: injection; nigrostriatal system; axonal transport; parkinson disease ... See more keywords
The Sphingolipid Asset Is Altered in the Nigrostriatal System of Mice Models of Parkinson’s Disease
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DOI: 10.3390/biom12010093
Abstract: Parkinson’s disease (PD) is a neurodegenerative disease incurable due to late diagnosis and treatment. Therefore, one of the priorities of neurology is to study the mechanisms of PD pathogenesis at the preclinical and early clinical… read more here.
Keywords: clinical stages; sphingolipid asset; nigrostriatal system; parkinson disease ... See more keywords
Changes in Tyrosine Hydroxylase Activity and Dopamine Synthesis in the Nigrostriatal System of Mice in an Acute Model of Parkinson’s Disease as a Manifestation of Neurodegeneration and Neuroplasticity
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci12060779
Abstract: The progressive degradation of the nigrostriatal system leads to the development of Parkinson’s disease (PD). The synthesis of dopamine, the neurotransmitter of the nigrostriatal system, depends on the rate-limiting enzyme, tyrosine hydroxylase (TH). In this… read more here.
Keywords: nigrostriatal system; parkinson disease; synthesis; neuroplasticity ... See more keywords