Depletion of NIMA-related kinase Nek2 induces aberrant self-renewal and apoptosis in stem/progenitor cells of aged muscular tissues
Sign Up to like & getrecommendations! Published in 2022 at "Mechanisms of Ageing and Development"
DOI: 10.1016/j.mad.2022.111619
Abstract: Frailty of the locomotory organs has become a widespread problem in the geriatric population. The major factor leading to frailty is an age-associated decrease in muscular mass and a reduced number of muscular cells and… read more here.
Keywords: muscular tissues; kinase nek2; self renewal; related kinase ... See more keywords
Overexpression of NIMA related kinase 2 in multiple myeloma and its relevance with disease features and prognosis to bortezomib treatment
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DOI: 10.1111/jcpt.13723
Abstract: NIMA related kinase 2 (NEK2) promotes the malignant transformation and enhances the chemoresistance to proteasome inhibitor in multiple myeloma (MM) cell lines. The current study aimed to further investigate its correlation with clinical features and… read more here.
Keywords: nima related; related kinase; multiple myeloma; bortezomib treatment ... See more keywords
NIMA-related kinase 2 overexpression is associated with poor survival in cancer patients: a systematic review and meta-analysis
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DOI: 10.2147/cmar.s188347
Abstract: Objective NIMA-related kinase 2 (NEK2) has been reported to be overexpressed in various types of cancer and correlated with poor prognosis. The role(s) of NEK2 in cancer, however, is still uncertain. The aim of this… read more here.
Keywords: meta analysis; nima related; cancer; cancer patients ... See more keywords
NIMA related kinase 2 promotes gastric cancer cell proliferation via ERK/MAPK signaling
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DOI: 10.3748/wjg.v25.i23.2898
Abstract: BACKGROUND NIMA related kinase 2 (NEK2) is closely related to mitosis, and it is currently considered to be over-expressed frequently in many poorly prognostic cancers. However, the effect of the up-regulated NEK2 on cellular signaling… read more here.
Keywords: nima related; erk; proliferation; related kinase ... See more keywords